357例中国皮肤黑色素瘤临床特征与预后分析

目的对357例皮肤黑色素瘤患者的临床特点进行分析，以了解其流行病学特点及预后相关因素。方法对我科近3年来收治的黑色素瘤患者的临床特点与预后进行记录与随访，用SPSS11.5软件，采用寿命表法进行生存分析及Cox回归进行分析。结果Ⅰ期患者的中位生存期超过144.0月，Ⅱ、Ⅲ、Ⅳ期患者的中位生存期分别为95.7月、132.0月和26.8月；肢端黑色素瘤218例(61.1%)；多因素分析发现，分期及溃疡是影响生存期的独立预后因子。结论肢端黑色素瘤发病率最高，所有患者的预后与初诊时的分期及溃疡密切相关。

A Clinical Characters and Prognosis Analysis on 357 Cases with Cutaneous Malignant Melanoma in China

ObjectiveWe studied the clinical characters of 357 cases with cutaneous malignant melanoma in our center to identify the epidemiological characteristics and prognostic factors of malignant melanoma in China. MethodsClinical data of 357 cases with cutaneous malignant melanoma in our center were analyzed by SPSS11.5 software and life-table method of survival analysis and Cox regression statistical multi-factor analysis were done. ResultsThe median survival time in stageⅠ patients was more than 144.0 months,and in stage Ⅱ, Ⅲ and Ⅳ was 95.7 ,132.0 and 26.8 months, respectively. Two hundred and eighteen cases (61.1%) were of acral malignant melanoma. Multivariate survival analysis showed that the staging at the first examination and ulceration were independent prognostic factors affecting survival. ConclusionThe incidence of acral malignant melanoma was the highest. Primary tumor in the extremities was the most common. The prognosis was closely related to the staging and ulceration.