| DcR3和HER-2/neu在60例大肠癌中表达及临床意义 |
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| 引用本文： | 朱群山,陈平,赵伟.DcR3和HER-2/neu在60例大肠癌中表达及临床意义[J].肿瘤学杂志,2011,17(8):610-613. |
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| 作者姓名： | 朱群山 陈平 赵伟 |
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| 作者单位： | 江苏省苏北人民医院,江苏扬州,225001 |
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| 摘 要： | 目的]探讨DcR3和HER-2/neu在大肠癌中的表达及与大肠癌的相关性。方法]应用免疫组化法分别检测正常大肠组织（n=10）、大肠癌组织（n=60）中DcR3和HER-2/neu的表达情况,分析两者表达与大肠癌临床病理特征的关系。结果]正常大肠组织中DcR3和HER-2/neu蛋白无表达。大肠癌组织中DcR3蛋白阳性表达率58.33%,DcR3蛋白的表达与患者年龄、性别、肿瘤大小、肿瘤部位、浸润深度等无关（P〉0.05）,与分化程度、淋巴结转移和TNM分期有关（P〈0.05）。大肠癌组织中HER-2/neu蛋白阳性表达率63.33%,HER-2/neu蛋白的表达与患者年龄、性别、肿瘤大小、肿瘤部位等无关（P〉0.05）,与浸润深度、TNM分期、淋巴结转移和分化程度有关（P〈0.05）。大肠癌中DcR3表达与HER-2/neu表达呈正相关（r=0.3781,P〈0.05）。结论]大肠癌中DcR3和HER-2/neu高表达,DcR3、HER-2/neu表达可能与肿瘤的恶性程度和恶性生物学行为有关。
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| 关 键 词： | 肠肿瘤 DcR3 HER-2/neu 免疫组织化学 |
The Expression of DcR3 and HER-2/neu in 60 Cases with Colorectal Cancer and its Clinical Significance |
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| ZHU Qun-shan,CHEN Ping,ZHAO Wei.The Expression of DcR3 and HER-2/neu in 60 Cases with Colorectal Cancer and its Clinical Significance[J].Journal of Oncology,2011,17(8):610-613. |
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| Authors: | ZHU Qun-shan CHEN Ping ZHAO Wei |
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| Institution: | ZHU Qun-shan,CHEN Ping,ZHAO Wei(Subei People's Hospital of Jiangsu Province,Yangzhou 225001,China) |
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| Abstract: | Purpose] To investigate the expression of DcR3 and HER-2/neu in colorectal cancer,and its relationship with colorectal cancer.Methods] The expression of DcR3 and HER-2/neu in the specimens of colorectal cancer(n=60) and corresponding adjacent normal tissues(n=10) were detected by immunohistochemistry method.The correlations of DcR3 and HER-2/neu expression with clinicopathological features were analyzed.Results] DcR3 and HER-2/neu in normal colorectal tissues were negative expression.The positive rate of... |
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| Keywords: | colorectal neoplasm DcR3 HER-2/neu immunohistochemistry |
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