63例Ⅰ~Ⅲ期肾细胞癌患者术后辅助治疗疗效及预后因素分析

目的研究肾细胞癌术后辅助治疗的疗效及影响患者远期生存的因素。方法回顾性分析63例肾细胞癌患者术后辅助治疗的效果，多因素分析影响生存期的因素。结果全组5年生存率为71.0%；病理分期Ⅰ、Ⅱ和Ⅲ期患者5年生存率分别87.7%、70.3%和42.9%（χ²=11.629,P=0.003），T1、T2和T3期患者的5年生存率分别为88.7%、63.9%和37.0%（χ²=11.850,P=0.003），N0和N1患者的5年生存率分别为78.0%和35.6%（χ²=8.599,P=0.003），有、无静脉瘤栓的患者5年生存率分别为31.3%和76.0%（χ²=8.108,P=0.004）。全组局部复发率和远处转移率分别为15.9%（10/63）和23.8%(15/63)。多因素分析表明T分期（P=0.021）、N分期（P=0.040）、手术切除（P=0.032）、术后生物化疗（P=0.022）、术后放疗（P=0.042）是影响患者总生存期的独立预后因素。结论TNM分期是患者能否远期生存的决定性因素，术后辅助生物化疗和辅助放疗可提高总生存率，但需要进一步大样本随机对照研究。

Treatment Effect and Prognostic Factors of Postoperative Therapy for 63 Patients with Renal Cell Carcinoma

Objective To study the long-term results and prognostic factors of postoperative treatment for patients with renal cell carcinoma who underwent the surgical resection.Methods Sixty-three patients with renal cell carcinoma who received postoperative treatment were enrolled into our retrospective study.We analyzed the 5-year survival rate,the occurrence of the local relapse and distant metastasis.The prognostic factors were determined by Cox proportional risk model.Reuslts The 5-year overall suruvival rate of...