| MKK4基因启动子区遗传变异与中国南方人群肺癌易感性的相关性研究 |
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| 引用本文： | 黄斌芳,吕嘉春,丘福满,刘斌. MKK4基因启动子区遗传变异与中国南方人群肺癌易感性的相关性研究[J]. 肿瘤, 2011, 31(12): 1082-1086. DOI: 10.3781/j.issn.1000-7431.2011.12.006 |
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| 作者姓名： | 黄斌芳 吕嘉春 丘福满 刘斌 |
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| 作者单位： | 1. 广州医学院附属广州市第十二人民医院分子流行病学研究室,广州,510620
2. 广州医学院化学致癌研究所,广州,510182 |
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| 基金项目： | 国家自然科学基金资助项目，广东省高等学校高层次人才资助项目，广东省科技计划项目 |
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| 摘 要： | 目的:探讨丝裂原活化蛋白激酶激酶4(mitogen-activated protein kinase kinase4,MKK4)基因启动子区单核苷酸多态性与中国南方人群肺癌发病风险的关系。方法:采用病例对照研究方法,收集800例肺癌病例和900例正常对照,采用TaqMan技术检测MKK4基因启动子区多态位点rs3826392(-1304T>G)的基因型。应用SAS9.3软件分析其与肺癌易感性的相关性。结果:MKK4基因启动子区-1304T>G基因型在对照组中的频率分布符合Hardy-Weinberg平衡(P=0.149),其在病例组和对照组的分布差异有统计学意义(P=0.001);与携带TT基因型个体相比,携带TG杂合子的个体患肺癌的风险下降25%[校正比值比(oddratio,OR)=0.75,95%可信区间(confidence interval,CI)=0.58～0.97],而携带GG变异纯合子者患肺癌的风险下降45%(校正OR=0.55,95%CI=0.33～0.94);随着变异型等位基因G的个数增加,肺癌发病风险逐步降低(P趋势<0.001)。结论:MKK4基因启动子区-1304T>G基因遗传变异可能降低肺癌发病风险。
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| 关 键 词： | 肺肿瘤 有丝分裂原激活蛋白激酶激酶类 多态现象,单核苷酸 疾病易感性 |
The association between a genetic variant in MKK4 gene promoter and lung cancer risk in Southern Chinese population |
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| HUANG Bin-fang,L Jia-chun,QIU Fu-man,LIU Bin. The association between a genetic variant in MKK4 gene promoter and lung cancer risk in Southern Chinese population[J]. Tumor, 2011, 31(12): 1082-1086. DOI: 10.3781/j.issn.1000-7431.2011.12.006 |
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| Authors: | HUANG Bin-fang L Jia-chun QIU Fu-man LIU Bin |
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| Affiliation: | HUANG Bin-fang,L(U) Jia-chun,QIU Fu-man,LIU Bin |
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| Abstract: | Objective:To investigate the association between the single nucleotide polymorphism(SNP) of mitogen-activated protein kinase kinase 4(MKK4) promoter and the risk of lung cancer development in Southern Chinese population.Methods:A hospital-based case-control study including 800 cases of lung cancer and 900 healthy controls was conducted.TaqMan assay was used to test the SNP of rs3826392(-1304T>G) in MKK4 promoter,and the software SAS 9.13 was used to analyze the association of MKK4 polymorphism and the susce... |
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| Keywords: | Lung neoplasms Mitogen-activated protein kinase kinases Polymorphism single nucleotide Disease susceptibility |
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