“化疗脑”的研究进展

化疗相关认知损害(chemotherapy-induced cognitive impairment,CICI)又称为"化疗脑"。越来越多的医学文献证据支持常规应用化疗会增加患者认知损害的风险。然而,目前尚未明确CICI的发病机制及其临床特征。在多数情况下,CICI尚处于诊断不足的状态,且现阶段还缺乏有效针对化疗脑的治疗和预防措施,因而影响肿瘤患者的生活质量。当前极有必要在多学科干预下,及时地对CICI进行诊断和处理。

Advances in the research of chemotherapy-induced cognitive impairment

To evaluate the efficacy and toxicity of paclitaxel liposome combined with nedaplatin as first-line chemotherapy for patients with advanced esophageal cancer.A total of 42 patients with pathologically confirmed advanced esophageal cancer were recruited into this study.On day 1,the patients were infused with 135 mg/m2 paclitaxel liposome followed by nedaplatin 80 mg/m2.This chemotherapy regimen was repeated every three weeks until the documented disease progression,unacceptable toxicity or patients' refusal.