Infection of human gastrointestinal cells by HIV-1 |
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| Authors: | M P Moyer R I Huot A Ramirez S Joe M S Meltzer H E Gendelman |
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| Affiliation: | Department of Surgery, University of Texas Health Science Center, San Antonio. |
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| Abstract: | Human immunodeficiency virus (HIV-1) infected and replicated in primary cultures of normal human ileal and colonic epithelial cells. Monocyte-tropic strains (ADA, 24, and 36) were better able to replicate in the gastrointestinal (GI) cells than the T-cell-tropic HIV strain HTLV-IIIB. In some cultures, virus replication persisted through several months. Intestinal epithelium may be an initial target and reservoir for HIV and a vector for virus dissemination and transmission. |
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