唾液中唾液酸、癌胚抗原测定在口腔鳞癌诊断中的意义

目的 探讨唾液中癌胚抗原(CEA)和唾液酸(SA)含量在口腔颌面部鳞癌诊断中的意义。方法 分别采用酶联免疫吸附(ELLISA)法检测22例口腔鳞癌、22例口腔良性肿瘤患者、40例正常人的CEA和SA含量。结果 SA含量在正常人组与良性肿瘤组间、良性肿瘤与鳞癌组间差异无显著性(P>0.05);正常人组低于鳞癌组(P<0.01)。CEA含量在正常人组低于良性肿瘤和鳞癌组(P<0.01);在鳞癌和良性肿瘤组间差异无显著性(P>0.05)。结论 开展唾液CEA和SA的测定,对诊断颌面部鳞癌具有一定的参考价值。

Significance of Carcinoembryonic Antigen and Salic Acid in Saliva of Patients with Squamous Cell Carcinoma of Oral and Maxillofacial Region

Objective To study the diagnostic value of carcinoembryonic antigen(CEA)and salic acid (SA) level in saliva of patients with malignant tumors. Methods ELLISA method was adopted to determine the SA level and ENZYMIC method was used to determine the CEA level in saliva of squamous cell carcinoma among 22 patients with benign tumors and 40 healthy adults. Results The results showed that SA and CEA in saliva of patients with oral and maxillofacial cancers were significantly higher than those in the saliva of patients with benign tumors and healthy adults( P < 0.01); there was no difference in CEA and SA between the patients with benign tumors and healthy adults (P > 0.05). Conclusion CEA and SA levels in aliva of patients with squamous cell carcinoma were much higher than those with benign tumors and healthy group. Saliva CEA and SA being used as tumor markers for an early diagnosis of squamous cell carcinoma in oral and maxillofacial region may be helpful.