| 体内代谢法研究糖类药物对大鼠CYP3A4的影响 |
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| 引用本文： | 石杰,耿美玉,曹勇,张新惠.体内代谢法研究糖类药物对大鼠CYP3A4的影响[J].中国药学杂志,2006,41(22):1738-1740. |
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| 作者姓名： | 石杰 耿美玉 曹勇 张新惠 |
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| 作者单位： | 1. 青岛市立医院药物研究室,山东,青岛,266011
2. 中国海洋大学海洋药物研究所,山东,青岛,266003 |
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| 基金项目： | 致谢：本试验的完成得到了中国海洋大学海洋药物研究所和天津药物研究院的大力支持. |
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| 摘 要： | 目的研究不同结构的糖类药物对肝药酶的影响,从而对这些新药进行安全性评价,并预测它们与其他药物合用的不良相互作用。方法通过研究肝药酶的专属探针药物的体内代谢过程的变化,进而判断不同结构糖类药物对这些酶有无诱导或抑制作用。结果SPMG对雌雄大鼠均有显著的抑制作用,但AOSC对CYP3A4无影响。结论结构不同的药物对CYP3A4的影响存在明显的差异,药物与各种与CYP3A4酶代谢有关的药物合用时,应充分考虑其对肝药酶的不同影响,以避免潜在的毒性或不良反应。
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| 关 键 词： | 糖类药物 肝药酶CYP3A4 体内 代谢法 |
| 文章编号： | 1001-2494（2006）22-1738-04 |
| 收稿时间： | 2005-08-11 |
| 修稿时间： | 2005-08-11 |
Effect of Oligo- and Poly- Saccharide on CYP3A4 Using the Metabolic Method in Vivo |
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| SHI Jie,GENG Mei-yu,CAO Yong,ZHANG Xin-hui.Effect of Oligo- and Poly- Saccharide on CYP3A4 Using the Metabolic Method in Vivo[J].Chinese Pharmaceutical Journal,2006,41(22):1738-1740. |
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| Authors: | SHI Jie GENG Mei-yu CAO Yong ZHANG Xin-hui |
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| Institution: | 1. Qingdao Municipal Hospital, Qingdao 266011, China ; 2. Marine Drug and Food Institute, Ocean University of China, Qingdao 266003, China |
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| Abstract: | OBJECTIVE To investigate the effects of oligo-and poly-saccharide on CYP3A4 for the safety assessment.METHODS The metabolic changes of midazolam as the probe drug was studied in vivo,then the inhibition or induction effects of oligo-and poly-saccharide with different structure were estimated.RESULTS SPMG inhibited CYP3A4 in vivo while no effect of AOSC was obtained.CONCLUSION There were obvious differences between the effects of oligo-and poly-saccharide on CYP3A4 enzymes.When oligo-and poly-saccharide are used combined with other drugs which are metablized by CYP3A4 enzyme,the different effects should be considered to avoid the potential adverse reactions. |
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| Keywords: | sugar-drug CYP3A4 in vivo metabolic method |
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