Recovery of preoptic-anterior hypothalamic functions after transplantation |
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Authors: | Verma S Kumar V M Gopinath G Sharma R Tandon P N |
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Institution: | Department of Physiology, All India Institute of Medical Sciences, New Delhi 110029 (India). |
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Abstract: | Kainic acid lesion of the medial preoptic area resulted in the impairment of the thermoregulation and disruption of the reproductive cycle in female rats. The preoptic-anterior hypothalamic area from fetal donor was transplanted into the lesioned area ofthe host. After transplantation, these animals showed signs of estrus cyclicity and a recovery in basal temperature towards normal. They also showed a reduced shift of body temperature on exposure to a hot environment. Thus the female rats, which received transplantation, showed some degree of recovery of functions which were disrupted by kainic acid lesions. |
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