The effects of paeoniflorin on LPS-induced liver inflammatory reactions |
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Authors: | In Deok Kim and Bae Jin Ha |
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Institution: | (1) Bowles Center for Alcohol Studies, School of Medicine, CB#7178 UNC-CH, Chapel Hill, NC 27599, USA;(2) Neuropharmacology Section, NIEHS, RTP, NC 27709, USA |
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Abstract: | Paeoniflorin (PF), a monoterpene glucoside, is a primary bioactive component of paeony, the root extract of Paeonia lactiflora. We tested the antioxidant effects of PF and its ability to prevent lipopolysaccharide (LPS)-induced oxidative stress. We
intraperitoneally administered PF (2.5, 5, or 10 mg/kg) to rats for 20 days. On day 21, we injected the rats with LPS 4 h
before sacrifice and measured serum levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, lactate
dehydrogenase as well as the levels of malondialdehyde, superoxide dismutase, catalase, and glutathione peroxidase in liver
whole-cell homogenates and mitochondrial fractions. LPS treatment increased levels of glutamate oxaloacetate transaminase,
glutamate pyruvate transaminase, lactate dehydrogenase, and malondialdehyde, but PF treatment blocked these increases. LPS
treatment also decreased antioxidant levels of superoxide dismutase, catalase, and glutathione peroxidase, but PF blocked
these decreases. PF also protected liver tissue, as shown by histopathology. These results suggest that PF can protect against
LPS-induced liver inflammation. |
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