Cover Picture: Eur. J. Immunol. 11'14

Our cover features a light micrograph of hematoxylin and eosin‐stained human myeloid‐derived suppressor cells (MDSCs). These CD33⁺IL‐4Rα⁺ cells were derived from umbilical cord blood precursors by culturing with hGM‐CSF and hG‐CSF, and the histology confirms a fibrocyte‐like morphology characterized by extended cytoplasm, multiple nucleoli in the nucleus, phagocytic extensions and high adhesion to plastic. The image is taken from Zoso et al., in which the authors show that this novel population of fibrocytic MDSCs drives Treg‐cell expansion and induces normoglycemia in a xenogeneic mouse model of Type 1 diabetes. The authors also show that direct contact between the fibrocyte‐like MDSCs and T cells is required for the tolerogenic effect, and that this process involves IDO production. This new MDSC subset may prove useful in the production of Treg cells for the treatment of autoimmune diseases.