三氯醋酸对金黄地鼠颊囊粘膜作用的实验研究

本研究旨在通过三氯醋酸对金黄地鼠颊囊粘膜作用的研究，了解其可能引起粘膜损伤的性质。为用于临床治疗提供理论依据。本试验是以金黄地鼠作为试验动物，２０％三氯醋酸作为涂布试剂，手术后不同时期处死动物，对标本行光镜和透射电镜观察。结果显示：２０％三氯醋酸可引起粘膜的坏死脱落，形成溃疡，坏死区由新生上皮替代，并且出现明显的纤维组织增生，提示：三氯醋酸用于口腔颌面部上皮性囊肿治疗，可能因上皮破坏治愈囊肿或降低

Study of effects of trichloroacetic acid on the pouch mucosa of Hamster

The purpose of this study wsa to explore the mechanism of injury of oral mucosa caused by 20% trichloroacetic acid (TCA). The method of this study was to spread 20% TCA on the buccal pouch mucosa of hamster and animals were sacrificed at different time postoperatively,The spicemens were studied by light microscopy and transmission electron microscopy. The results as follows: 20%TCA caused epithelial necrosis and ulcer formation. At 3 weeks postoperatively. buccal pouches were reepithelized and reaction of enzyme histochemistry reappeared and there were an apparent increase in the amount of collagen and fibroblast. The results suggest: 20% TCA is a kind of cauterizing agent.Which can cause necrosis of mucosa. If epithelial cysts were treated with 20% TCA. It's possible to cure the cysts or decrease their recurrence.