| 他汀类药物相关抗HMGCR抗体介导坏死性肌病的研究进展 |
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| 引用本文： | 焦宇琼,林洁,蔡爽,奚剑英,朱雯华,赵重波,卢家红. 他汀类药物相关抗HMGCR抗体介导坏死性肌病的研究进展[J]. 中国临床神经科学, 2017, 0(2): 191-197. DOI: 10.3969/j.issn.1008-0678.2017.02.009 |
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| 作者姓名： | 焦宇琼 林洁 蔡爽 奚剑英 朱雯华 赵重波 卢家红 |
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| 作者单位： | 复旦大学附属华山医院神经内科 200040 |
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| 摘 要： | 抗3-羟基3-甲基戊二酰辅酶A还原酶(HMGCR)抗体介导的坏死性肌病是近年逐渐被认识的一类疾病,该病与他汀类药物的使用密切相关。患者具有坏死性肌病的一般特点,通过抗HMGCR抗体阳性与其他类型的坏死性肌病相鉴别。多数患者可通过激素联合其他免疫抑制剂治疗可控制病情。文中回顾了该病的发病机制、流行病学、临床特点、诊断及鉴别诊断、治疗等研究现状,以加强临床医生对该病的认识。
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| 关 键 词： | 他汀类药物 抗3-羟基3-甲基戊二酰辅酶A还原酶抗体 坏死性肌病 临床特点 诊断标准 治疗 |
Necrotizing Myopathy Related to Anti-3-hydroxy-3-methylglutaryl-coenzyme A Reductase Antibody |
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| JIAO Yu-qiong,LIN Jie,CAI Shuang,XI Jian-ying,ZHU Wen-hua,ZHAO Chong-bo,LU Jia-hong. Necrotizing Myopathy Related to Anti-3-hydroxy-3-methylglutaryl-coenzyme A Reductase Antibody[J]. Chinese Journal of Clinical Neurosciences, 2017, 0(2): 191-197. DOI: 10.3969/j.issn.1008-0678.2017.02.009 |
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| Authors: | JIAO Yu-qiong LIN Jie CAI Shuang XI Jian-ying ZHU Wen-hua ZHAO Chong-bo LU Jia-hong |
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| Abstract: | Anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) antibody mediated necrotizing myopathy is gradually known by clinical doctors in recent years.Its incidence is low.Statins may be a triggering factor of this disease.Patients have the general characters of necrotizing myopathy,and can be distinguished from other kinds of necrotizing myopathy by anti-HMGCR antibody positive.Glucocorticoids are the most common initial immunosuppressive agent,but other kinds of immunosuppressants are often necessary.The etiology,epidemiology,clinical characteristics,diagnosis and treatment of anti-HMGCR antibody-mediated autoimmune necrotizing myopathy were reviewed. |
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| Keywords: | statin anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibody necrotizing myopathy clinical features diagnostic criteria therapy |
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