急性ST段抬高型心肌梗死中医证型与N端脑钠肽前体、超敏C反应蛋白关系研究

目的：研究急性ST段抬高型心肌梗死（STEMI）患者中医证型与N端脑钠肽前体、超敏C反应蛋白水平关系。方法：纳入STEMI患者167例作为实验组,确定中医辨证分型,另外选择健康体检者50例为对照组,实验组和对照组均采集静脉血检测NT-pro BNP,hs-CRP水平。结果：STEMI组患者血清NT-pro BNP为（1 636.62±538.90）pg/m L,明显高于对照组（46.72±24.64）pg/m L（P〈0.05）;STEMI组患者血清hs-CRP为（16.45±3.64）mg/L,明显高于对照组（2.47±0.74）mg/L（P〈0.05）。心血瘀阻证患者血清NT-pro BNP（2 801.52±732.87）pg/m L、hs-CRP（30.67±5.77）mg/L水平明显高于其他证型患者,差异有显著性（P〈0.05）,NTpro BNP与hs-CRP呈正相关性（r=0.503,P=0.034 P〈0.05）。结论：NSTEMI患者血清NT-pro BNP,hsCRP明显升高,且心血瘀阻证中医证候与NT-pro BNP、hs-CRP密切相关。

Study on Relationship in TCM Syndrome of Acute ST-Elevation Myocardial Infarction,N-terminal Pro-brain Natriuretic Peptide and Supersensitivity C-reactive Protein

Objective： to study the relationship between the TCM syndrome of acute STEMI,N-terminal Pro-brain Natriuretic Peptide and CRP. Methods： 167 cases with STEMI were taken as experimental group with syndrome differentiation classification,while 50 healthy people for medical examination as control group. Venous blood were collected from both groups to detect NT-pro BNP and hsCRP. Results： NT-pro BNP of STEMI group（ 1636. 62 ± 538. 90） pg / m L was significantly higher than that of control group（ 46. 72 ±24. 64） pg / m L（ P〈0. 05）; hs-CRP（ 16. 45 ± 3. 64） mg / L was significantly higher than that of control group（ 2. 47 ± 0. 74） mg / L（ P〈0. 05）. Of patients with heart blood stasis syndrome,NT-pro BNP（ 2801. 52 ± 732. 87） pg/m L and hs-CRP（ 30. 67 ± 5. 77）mg / L were higher than those of other syndromes,with significant difference（ P〈0. 05）. There was a positive correlation between NT-pro BNP and hs-CRP（ r = 0. 503,P = 0. 034 P〈0. 05）. Conclusion： NT-pro BNP and hs-CRP of NSTEMI patients increase significantly,and heart blood stasis syndrome is closely correlated to NT-pro BNP and hs-CRP.