非霍奇金淋巴瘤化疗疗效影响因素分析 |
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引用本文: | 周旻,喻庆薇,柳子川,蔡植华,彭如筠,金学军.非霍奇金淋巴瘤化疗疗效影响因素分析[J].陕西医学杂志,2010,39(7):812-813,816. |
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作者姓名: | 周旻 喻庆薇 柳子川 蔡植华 彭如筠 金学军 |
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作者单位: | 广州医学院附属肿瘤医院,广州,510095 |
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摘 要: | 目的:分析影响非霍奇金淋巴瘤化疗疗效的主要因素。方法:选择初治非霍奇金淋巴瘤(NHL)患者135例,病理诊断为T或B细胞NHL,分别按T或B细胞病理类型、国际预后指数(IPI)≤2或>2、有无结外侵犯、肿瘤直径≤5cm或>5cm各分两组,所有患者给予CHOP方案化疗3次,分别比较各组的总有效率。结果:B细胞型NHL总有效率(75%)和T细胞型NHL总有效率(55.8%),IPI≤2组NHL总有效率(73.4%)和IPI>2组NHL总有效率(52.1%),无结外侵犯组NHL总有效率(73.8%)和有结外侵犯组NHL总有效率(42.9%)的差异有统计学意义。肿瘤直径≤5cm组总有效率(69.9%)与肿瘤直径>5cm组NHL总有效率(50%)差异无统计学意义。结论:肿瘤病理类型、IPI和结外器官侵犯可能响NHL化疗疗效的因素,肿瘤直径可能不是影响NHL化疗疗效的因素。
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关 键 词: | 淋巴瘤 非霍奇金/药物疗法 治疗结果 @影响因素 |
Analysis of factors influencing the efficacies of chemotherapy for non-Hodgkin's lymphoma |
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Institution: | Affiliated Tumor Hospital of Guangzhou Medical College (Guangzhou 510095) Zhou Min Yu Qingwei Liu Zichuan et al |
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Abstract: | Objective:To analyze the main factors influencing the efficacies of CHOP regiment in treating non-Hodgnin’s Lymphoma (NHL).Methods:135 patients first diagnosed as T-cell NHL or B-cell NHL were observed.They were divided respectively into two groups according to pathologic type,international prognostic index (IPI),extranodal involvement,tumor diameter.All patients received CHOP regiment at 3 cycles.The total response rates (RR) of each group containing complete remission (CR) rate and partial remission (PR) rate were compared respectively.Results:The differences of total response rates (RRs) between B-cell NHL group (75%) and T-cell NHL group (55.8%),the group of IPI less than or equal to 2 (73.4%) and the group of IPI more than 2 (52.1%),no extranodal involvement group (73.8%)and extranodal involvement group(42.9%)were significant.The RR at group of tumor diameter less than 5 cm was 69.9%,the RR at group of tumor diameter more than 5 cm was 50%,the difference between two groups was no significant.Conclusion:These data shows that pathologic type,IPI and extranodal involvement,except tumor diameter,are possible factors to influence the efficacies of chemotherapy for NHL. |
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Keywords: | Lymphoma non-hodgkin/drug therapy Treatment outlcome @Influential factor |
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