肺康颗粒对缺氧大鼠肺动脉高压血管内皮损伤的保护作用

目的：研究肺康颗粒对缺氧性肺动脉高压血管内皮损伤的保护作用。方法：以缺氧叠加静脉注射三氯化铁建立缺氧性肺动脉高压动物模型，治疗于每天缺氧后ig给予肺康颗粒。7d后测定血浆内皮素(ET)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)含量和谷胱甘肽过氧化物酶(GSH-PX)活力。结果：(1)缺氧组大鼠上述检测指标较对照组显著升高。提示缺氧导致大鼠体内参与氧化反应系列酶水平明显失衡，发生较明显肺动脉高压及血管内皮损伤。(2)洽疗后ET和MDA水平，SOD含量和GSH-PX活力有明显回落。提示治疗组大鼠肺动脉高压显著下降，内皮细胞损伤、参与氧化反应系列酶水平失衡等病理改变有所改善。结论：肺康颗粒对缺氧性肺动脉高压血管内皮损伤有一定的保护作用。

Protective effect of Feikang Granules on endodermis scathe of pulmonary vascular in rats with hypoxia-induced pulmonary hypertension

Objective: To investigate the protective effect of Feikang Granules (FK) on endodermis scathe of pulmonary vascular in rats with hypoxia induced pulmonary hypertension (HPH). Methods: Hypoxia with intravenous injection FeCl 3 was used to establish model rats with HPH. Hypoxia rats were treated with FK for seven days after hypoxia everyday. Plasma endothelin (ET), superoxide dismutase (SOD), malondialdehyde (MDA) and glutathione peroxidase (GSH PX) in serum were inspected. Results: (1) Those indexes were higher remarkably than control group and showed that the level of series enzyme concerned with oxidation reaction was in unbalance. Pulmonary hypertension and endodermis scathe of pulmonary vascular had happened. (2) The level of ET, MDA, SOD and GSH PX decreased significantly in the treated group. It indicated that FK could inhibit HPH and improve the pathological changes such as endodermis scathe, the unbalance of series enzyme concerned with oxidation reaction. Conclusion:Feikang Granules may partly prevent the development of HPH and endodermis scathe of pulmonary vascular.