中西医结合治疗急性痛风性关节炎疗效观察

目的:观察中西医结合治疗急性痛风性关节炎的临床疗效。方法:60例急性痛风性关节炎患者,按随机数字表法分为两组,每组各30例。对照组在一般性治疗的同时用碳酸氢纳片、依托考昔片口服治疗;观察组在对照组基础上,外敷金黄膏、口服加味四妙汤治疗。观察2个疗程(14天)后两组临床疗效、疼痛缓解时间以及药物不良反应,采用常规生化方法测定治疗前后两组血尿酸(UA)和C反应蛋白(CRP)水平变化;随访治疗有效患者半年内复发情况。结果:2个疗程结束后,观察组总有效率(93.33%)优于对照组(70.00%)(P0.05);疼痛缓解时间短于对照组(P0.01);两组治疗后血UA、CRP与治疗前比较,均有显著下降(P0.01),且观察组较对照组降低更明显(P0.05);观察组复发率低于对照组(P0.05);两组均未见严重不良反应。结论:中西医结合治疗急性痛风性关节炎能提高疗效,降低复发率。

Observation on the Efficacy of Combination Therapy in Acute Gouty Arthritis

Objective：To observe the clinical effects of combination therapy in acute gouty arthritis.Method：60 cases of a-cute gouty arthritis patients were divided into two groups by random number table （30 cases each）.we gave the con-trol group general treatment and sodium bicarbonate tablets with etoricoxib;meanwhile,besides the therapy of the control group we gave the observation group golden cream to use topically,and Jia Wei Si Miao decoction to take o-rally.Two courses （14 days）later we observed the clinical efficacy,the pain relief time and the adverse reactions of the drug;and measured serum uric acid （UA）and C-reactive protein （CRP）levels by conventional biochemical methods before and after treatment;last we statistics the recurrence rate of those whose treatment was effective within six months.Results：After two courses the total effective rate of the observation group was 93.33% com-pared with 70.00% of the control group （P〈0.05）;pain relief time was shorter than the control group （P〈0.01）, the levels of UA and CRP after treatment in the two groups were significantly lower than the levels before the treat-ment （P〈0.01）;the levels in the observation group were significantly decreased than the control group（P〈0.05）;and the recurrence rate of observation group was lower than that of the control group （P〈0.05）.Conclusion：The integra-tive treatment for acute gouty arthritis can improve the clinical effects,and also can reduce the recurrence rate.