左旋门冬氨酸鸟氨酸治疗非酒精性脂肪性肝炎的临床观察

目的　探讨左旋门冬氨酸鸟氨酸 (雅博司 )治疗非酒精性脂肪性肝炎及降低血清甘油三酯水平的效果。方法　 30例经肝功能、B超检查及肝穿病理学检查确诊为非酒精性脂肪性肝炎患者 ,应用左旋门冬氨酸鸟氨酸 10g加入 10 %葡萄糖中静脉滴注 ,每日 1次 ,持续 2 1d ,疗程结束后复查血清丙氨酸转氨酶 (ALT)、天冬氨酸转氨酶 (AST)及甘油三酯。结果　 30例患者中 ,2 9例( 96 7% )血清ALT和AST恢复正常 ,2 8例 ( 93 3% )血清甘油三酯水平恢复正常 ,治疗期间无明显毒副作用。结论　左旋门冬氨酸鸟氨酸是一种治疗非酒精性脂肪性肝炎安全有效的药物 ,同时可降低血清甘油三酯水平。

A clinical study on treatment for nonalcoholic steatohepatitis with L-ornithine-L-aspartate

Objective To study efficacy of L-ornithine-L-aspartate (Hepa-Merz) in treatment for nonalcoholic steatohepatitis (NASH) and its effect on lowering serum level of triglycerine MethodsTotally, 30 patients with nonalcoholic steatohepatitis diagnosed by liver function test, B ultrasound scanning and liver biopsy were treated by intravenous infusion of L ornithine L aspartate (Hepa Merz) 10 g daily for 21 days Activities of serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and serum level of triglycerine (TG) were determined for all the cases before and after treatment Results Activities of serum ALT and AST and serum level of TG were restored to normal in 29 (96 7%) and in 28 (93 3%) of 30 patients, respectively, after treatment No serious adverse effects were found during treatment Conclusions L ornithine L aspartate (Hepa Merz) is a safe and effective drug in treatment for nonalcoholic steatohepatitis, and can lower serum level of triglycerine significantly