心肌肌钙蛋白I在检测急性心肌梗死中的诊断价值

目的:探讨心肌肌钙蛋白I(cTnI)对急性心肌梗死(AMI)的早期诊断价值。方法:对38例AMI患者、35例不稳定性心绞痛(UAP)患者、26例骨骼肌损伤(SM)患者和25例健康者进行血清cTnI、CK-MB(肌酸磷酸激酶同工酶)测定,并对AMI患者胸痛发生不同时段cTnI、CK-MB值进行动态观测。结果:AMI患者入院时cTnI、CK-MB的阳性检出率分别为68.5%和56.3%。CK-MB在UAP组和SM组有较高的阳性率,而cTnI在UAP和SM组未检出。cTnI在AMI发生4h内即显著升高,两项指标的最高峰值在8~16h内均可出现,72h后CK-MB降至临界值,而cTnI在7d后仍高于对照组。结论:cTnI在AMI早期具有重要的诊断价值,因其具有较宽的时间诊断窗口和独特的特异性,所以是AMI早期诊断较敏感和特异的血清标志物。

The Diagnostic Value of cTnI for Acute Myocardial Infarction

Objective：To investigate the early diagnostic value of cardiac troponin Ⅰ （cTnⅠ） for acute myocardial infarction （AMI）. Methods. In 38 patients with AMI, 35 cases of unstable angina pectoris （UAP）, 26 cases of muscle damage （SM）and 25 healthy persons the serum cTnl and CK-MB levels were determined, the cTnⅠ and GK-MB values were dynamically observed for the chest pain patients with AMI in different time. Results. The cTnⅠ, CK-MB positive rates were 68. 5% and 56. 3% in AMI patients at the time of admisson. CK-MB in the UAP group arid the SM group had higher positive rate. while cTnⅠ was not found out in UAP and the SM groups. The cTnl level significantly increased within 4 hours after AMI. The peak values of the two indicators appeared in the 8-16 hours, CK-MB decreased to the critical value after 72 hours, and cTnl level was still higher than that in the control group in 7 days. Condusion z cTnl is of importance in early diagnosis of AMI, because it has a wide window of time and specifcity.