Thrombotic thrombocytopenic purpura in advanced prostate cancer: Case report and published work review |
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| Authors: | Valeria Caramello rea Dovio Pasquale Caraci Alfredo Berruti Alberto Angeli |
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| Affiliation: | Internal Medicine, Department of Clinical and Biological Sciences, University of Turin, San Luigi Hospitals, Orbassano, Turin, Italy. cara.vale@tin.it |
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| Abstract: | Thrombotic thrombocytopenic purpura (TTP) is a generalized disorder of the microcirculation characterized by microangiopathic hemolytic anemia (MHA), thrombocytopenic purpura and systemic microvascular thrombi. TTP has been previously described in two patients with prostate cancer (PC). We report a third case of TTP in a 61-year-old man with hormone-refractory bone metastatic PC. The syndrome presented with confusion, anuric acute renal failure, thrombocytopenia and MHA. A satisfactory recovery was achieved after plasma exchange (PE). TTP should be included in the coagulation disorders occurring in PC patients. Early treatment with plasma exchange is recommended in these particular cases. |
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| Keywords: | acute renal failure microangiopathic hemolytic anemia plasma exchange prostate cancer thrombotic thrombocytopenic purpura |
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