Short-term dietary conjugated linoleic acid supplementation does not enhance the recovery of immunodepleted dexamethasone-treated rats |
| |
Authors: | Turini Marco E Boza Julio J Gueissaz Nathalie Moënnoz Denis Montigon Frank Vuichoud Jacques Gremaud Gérard Pouteau Etienne Piguet Christelle Perrin Irène Verguet Clotilde Finot Paul-André German Bruce |
| |
Institution: | (1) Dept. of Nutrition, Nestlé Research Center, Nestec Ltd., P. O. Box 44, 1000 Lausanne 26, Switzerland. marco.turini@rdls.nestle.com, CH |
| |
Abstract: | Summary. Background: Conjugated linoleic acid (CLA) has been reported to decrease fat deposition, and increase lean body mass. This has been broadly
inferred to mean that CLA alters protein turnover. However, data to test the effects of CLA on protein turnover are lacking.
An enhancement in immune responses by CLA has also been demonstrated. Aim of the study: The objective of this study was to determine the potential for dietary CLA and protein intervention to improve nutritional
and functional recovery in an animal model of catabolic stress and immunodepletion. Methods: Diets varying in their protein levels in the presence or absence of CLA were tested for their effects on the recovery of
glucocorticoid (intraperitoneal injection of dexamethasone, 120 mg/kg) treated rats. Following steroid injection, rats were
fed 4 dietary treatments for 4 d. The diets contained 10 or 20 g/100 g protein with or without 0.5 g/100 g CLA. Results: Dexamethasone treatment resulted in a decreased food intake and loss of weight, independent of dietary treatment. A higher
number of blood monocytes occurred in rats fed the high CLA diets. The protein fractional synthesis rate in spleens of rats
fed the diets containing either high proteins or CLA were higher compared to those fed diets with low protein content or without
CLA, respectively. CLA, consumed post-dexamethasone treatment, did not improve protein turnover in the other tissues studied,
including gut mucosa, liver, muscle and thymus. Conclusions: The present study was performed to determine the effect of CLA in acute conditions, as opposed to a preventive approach,
on the recovery from a catabolic stress with immunodepletion. Overall, no effect of short-term feeding CLA on the recovery
from dexamethasone-mediated immunodepletion was observed.
Received: 23 July 2002, Accepted: 31 January 2003
Correspondence to: Marco E. Turini |
| |
Keywords: | conjugated linoleic acid – dexamethasone – protein synthesis – white blood cells – rats |
本文献已被 PubMed SpringerLink 等数据库收录! |
|