体检人群血清尿酸浓度与心血管病危险因素的关系

目的分析本院体检人群血清尿酸浓度及其与心血管疾病危险因素的关系。方法记录在本院进行健康体检的24 965人的性别、年龄,测量受检者的身高、体质量、体质量指数、收缩压、舒张压,检测他们的血清尿酸、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖浓度。进一步分析血清尿酸浓度及其影响因素的关系。结果宁波市人群血清尿酸浓度(312.01±89.26)μmol/L,男性血清尿酸值明显高于女性,差异有统计学意义(359.71±75.71)μmol/L vs.(244.95±58.40)μmol/L,P0.001]。各心血管危险因素在控制其他危险因素后与血清尿酸浓度进行偏相关分析:年龄(r=0.0272,P0.001)、体质量指数(r=0.191,P0.001)、舒张压(r=0.130,P0.001)、总胆固醇(r=0.047,P0.001)、三酰甘油(r=0.025,P0.001),均与血清尿酸浓度呈正相关;而空腹血糖(r=-0.081,P0.001)、低密度脂蛋白胆固醇(r=-0.045,P0.001)、高密度脂蛋白胆固醇(r=-0.110,P0.001)均与血清尿酸浓度呈负相关;收缩压与血清尿酸浓度无相关性(r=-0.001,P0.857)。结论本院体检人群血清尿酸浓度较高,血清尿酸浓度升高与多种心血管危险因素相关。

Relationship between concentration of serum uric acid and risk factors of cardiovascular disease in population of healthy examination

Objectives To analyze relationship between the concentration of serum uric acid and its risk factors of cardiovascular disease among residents in population of healthy examination.Methods Totally 24 965 people were investigated during physical examination by recording their genders and age,measuring their height,weight,body mass index（BMI）,systolic blood pressure（SBP） and diastolic blood pressure（DBP）,concentrations of serum uric acid（SUA）,total cholesterol（TC）,triglycerides（TG）,serum high density lipoprotein cholesterol（HDL-C）,serum low density lipoprotein cholesterol（LDL-C） and fasting blood glucose（FBG）.We analyzed the relationship of concentration of serum uric acid and its influencing factors.Results The concentration of SUA was（312.01±89.26） μmol/L in these Ningbo residents.The concentration of SUA was significantly higher in male than in female（359.71±75.71）μmol/L vs.（244.95±58.40）μmol/L,P0.001].There was a significantly positive correlativity among concentration of SUA and age（r=0.0272,P0.001）,BMI（r=0.191,P0.001）,DBP（r=0.130,P0.001）,TC（r=0.047,P0.001）,TG（r=0.025,P0.001）;FBG（r=-0.081,P0.001）,LDL-C（r=-0.045,P0.001）,HDL-C（r=-0.110,P0.001） were significantly negative correlated with concentration of SUA.There was no correlativity between concentration of SUA and SBP.Conclusions Concentration of SUA is high among residents in population of healthy examination.High concentration of SUA is significantly correlated with multiple cardiovascular risk factors.