Correlation of magnetic resonance images with neuropathology in acute Wernicke's encephalopathy |
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Authors: | Liu Yo-Tsen Fuh Jong-Ling Lirng Jiing-Feng Li Anna Fen-Yau Ho Donald Ming-Tak Wang Shuu-Jiun |
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Affiliation: | The Neurological Institute, Taipei Veterans General Hospital, #201 Shi-Pai Road, Sec 2, Taipei 11217, Taiwan. |
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Abstract: | We correlated serial brain MRIs with neuropathological findings in a 16-year-old female whose autopsy was consistent with Wernicke's encephalopathy (WE). Diffusion-weighted imaging, diffusion coefficients mapping and neuropathology findings were suggested vasogenic edema in the periaqueductal and peri-the-fourth ventricular areas. This is the first documented case report to make this direct comparison. The characteristic WE changes in the mammillary body was also correlated with the findings of MRI with contrast enhancement. Bilateral cortical lesions revealed by MRI were atypical and rare in WE and were not evidenced by pathological changes. |
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Keywords: | Acute Wernicke's encephalopathy Diffusion-weighted Magnetic Resonance imaging Vasogenic edema |
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