Altered Intestinal ACE2 Levels Are Associated With Inflammation,Severe Disease,and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Altered Intestinal ACE2 Levels Are Associated With Inflammation,Severe Disease,and Response to Anti-Cytokine Therapy in Inflammatory Bowel Disease

Authors:	Alka A Potdar Shishir Dube Takeo Naito Katherine Li Gregory Botwin Talin Haritunians Dalin Li David Casero Shaohong Yang Janine Bilsborough Jacqueline G Perrigoue Lee A Denson Mark Daly Stephan R Targan Phillip Fleshner Jonathan Braun Subra Kugathasan Thaddeus S Stappenbeck Dermot PB McGovern

Institution:	1. F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California;2. Janssen Research and Development, LLC, Spring House, Pennsylvania;3. Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Cincinnati College of Medicine and the Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio;4. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts;5. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts;6. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia;7. Children’s Healthcare of Atlanta, Atlanta, Georgia;8. Department of Inflammation and Immunity, Cleveland Clinic, Cleveland, Ohio;1. Gastroenterology Unit, Massachusetts General Hospital, Boston, Massachusetts;2. Massachusetts General Hospital Institute of Health Professions, Boston, Massachusetts;3. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston, Massachusetts;4. Harvard Medical School, Boston, Massachusetts;1. California Medical Innovations Institute, San Diego, California;2. 3DT Holdings, San Diego, California;1. Jill Roberts Center for IBD, Division of Gastroenterology and Hepatology, New York Presbyterian Hospital- Weill Cornell Medical Center, New York, New York;2. Department of Pathology and Laboratory Medicine, New York Presbyterian Hospital- Weill Cornell Medical Center, New York, New York;1. Division of Genetic Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee;2. Genome Technology Access Center, McDonnell Genome Institute, St Louis, Missouri;3. Epithelial Biology Center and the Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, Tennessee;4. University of Cincinnati Children’s Medical Hospital Research Center, Cincinnati, Ohio;5. Northeastern University, Department of Biology, Boston, Massachusetts;6. Office of Shared Resources, Vanderbilt University School of Medicine, Nashville, Tennessee;1. Department of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom;2. Department of Paediatric Gastroenterology, Hepatology and Nutrition, Cambridge University Hospitals, Addenbrooke’s, Cambridge, United Kingdom;3. Wellcome Trust-Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom;4. European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom;5. Academic Coloproctology, Western General Hospital, Edinburgh, Edinburgh, United Kingdom;6. Medical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom;7. Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom;8. Medical Research Council London Institute of Medical Sciences, United Kingdom;8. Institute of Clinical Sciences, Imperial College London, United Kingdom

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Keywords:	Crohn’s Disease Ulcerative Colitis Infliximab Ustekinumab ACE"} {"#name":"keyword" "$":{"id":"kwrd0035"} "$$":[{"#name":"text" "_":"angiotensin-converting enzyme BMI"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"body mass index CD"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"Crohn’s disease cCD"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"Crohn’s disease with no small bowel or ileal disease COVID-19"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"coronavirus disease 2019 CSMC"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"Cedars-Sinai Medical Center FC"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"fold-change GI"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"gastrointestinal IBD"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"inflammatory bowel disease iCD"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"Crohn’s disease with ileum involvement IL"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"interleukin ISG"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"interferon-stimulated gene mRNA"} {"#name":"keyword" "$":{"id":"kwrd0155"} "$$":[{"#name":"text" "_":"messenger RNA SARS-CoV2"} {"#name":"keyword" "$":{"id":"kwrd0165"} "$$":[{"#name":"text" "_":"severe acute respiratory syndrome coronavirus 2 RAAS"} {"#name":"keyword" "$":{"id":"kwrd0175"} "$$":[{"#name":"text" "_":"renin–angiotensin–aldosterone system RNA-seq"} {"#name":"keyword" "$":{"id":"kwrd0185"} "$$":[{"#name":"text" "_":"RNA sequencing SB"} {"#name":"keyword" "$":{"id":"kwrd0195"} "$$":[{"#name":"text" "_":"small bowel TNF"} {"#name":"keyword" "$":{"id":"kwrd0205"} "$$":[{"#name":"text" "_":"tumor necrosis factor UC"} {"#name":"keyword" "$":{"id":"kwrd0215"} "$$":[{"#name":"text" "_":"ulcerative colitis WashU"} {"#name":"keyword" "$":{"id":"kwrd0225"} "$$":[{"#name":"text" "_":"Washington University
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