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Fecal Mycobiota Combined With Host Immune Factors Distinguish Clostridioides difficile Infection From Asymptomatic Carriage
Authors:Yangchun Cao  Lamei Wang  Shanlin Ke  Javier A Villafuerte Gálvez  Nira R Pollock  Caitlin Barrett  Rebecca Sprague  Kaitlyn Daugherty  Hua Xu  Qianyun Lin  Junhu Yao  Yulin Chen  Ciarán P Kelly  Yang-Yu Liu  Xinhua Chen
Institution:1. College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi Province, China;2. Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts;3. Channing Division of Network Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts;4. Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts;5. Department of Laboratory Medicine, Boston Children’s Hospital, Boston, Massachusetts;1. Division of Gastroenterology and Hepatology, University of Florida, Gainesville, Florida;2. Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts;3. Division of Gastroenterology and Hepatology, Hartford Hospital, Hartford, Connecticut;4. Division of Gastroenterology and Hepatology, Johns Hopkins Medical Center, Baltimore, Maryland;5. Division of Gastroenterology and Hepatology, Northwestern Medicine Digestive Health Center, Chicago, Illinois;6. Gastroenterology and Hepatology Section, Baylor College of Medicine, Houston, Texas;7. Division of Interventional Endoscopic Oncology and Surgical Endoscopy, Parkview Health, Fort Wayne, Indiana;8. Division of Gastroenterology and Hepatology, University of North Carolina Hospitals, Chapel Hill, North Carolina;9. Division of Gastroenterology and Hepatology, The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada;10. Division of Gastroenterology and Hepatology, The Medical University of South Carolina, Charleston, South Carolina;11. Division of Gastroenterology and Hepatology New York-Presbyterian Hospital/Weill Cornell Medical Center, New York, New York;12. Division of Gastroenterology and Hepatology, Thomas Jefferson University Hospitals, Philadelphia, Pennsylvania;13. Division of Hospital Gastroenterology, Atrium/Navicent Health, Mercer University, College of Medicine, Macon, Georgia;14. Division of Gastroenterology and Hepatology, University of Virginia, Charlottesville, Virginia;1. Department of Radiology, APHP.Nord, Hopital Beaujon, Clichy, France;2. Université de Paris, Paris, France;3. Department of Hepatobiliary Surgery, APHP Nord, Hopital Beaujon, Clichy, France;1. Department of Internal Medicine;2. Department of Pathology;3. Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio
Abstract:
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  • Keywords:Diagnostics  Gut Mycobiome  Immune Response  ANCOM"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"analysis of composition of microbiomes  AUC"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"area under the curve  Carrier"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"asymptomatic carriers  CDI"}  {"#name":"keyword"  "$":{"id":"kwrd0065"}  "$$":[{"#name":"text"  "$$":[{"#name":"italic"  "_":"Clostridioides difficile"}  {"#name":"__text__"  "_":" infection  GCSF"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"granulocyte colony-stimulating factor  Ig"}  {"#name":"keyword"  "$":{"id":"kwrd0085"}  "$$":[{"#name":"text"  "_":"immunoglobulin  IL"}  {"#name":"keyword"  "$":{"id":"kwrd0095"}  "$$":[{"#name":"text"  "_":"interleukin  ITS2"}  {"#name":"keyword"  "$":{"id":"kwrd0105"}  "$$":[{"#name":"text"  "_":"internal transcribed spacer 2  MCP1"}  {"#name":"keyword"  "$":{"id":"kwrd0115"}  "$$":[{"#name":"text"  "_":"monocyte chemoattractant protein 1  NAAT"}  {"#name":"keyword"  "$":{"id":"kwrd0125"}  "$$":[{"#name":"text"  "_":"nucleic acid amplification testing  OTU"}  {"#name":"keyword"  "$":{"id":"kwrd0135"}  "$$":[{"#name":"text"  "_":"operational taxonomic unit  PERMANOVA"}  {"#name":"keyword"  "$":{"id":"kwrd0145"}  "$$":[{"#name":"text"  "_":"permutational multivariate analysis of variance  TNF"}  {"#name":"keyword"  "$":{"id":"kwrd0155"}  "$$":[{"#name":"text"  "_":"tumor necrosis factor
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