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Mesenchymal Plasticity Regulated by Prrx1 Drives Aggressive Pancreatic Cancer Biology

Authors:	Karin Feldmann Carlo Maurer Katja Peschke Steffen Teller Kathleen Schuck Katja Steiger Thomas Engleitner Rupert Öllinger Alice Nomura Nils Wirges Aristeidis Papargyriou Rim Sabrina Jahan Sarker Raphela Aranie Ranjan Zahra Dantes Wilko Weichert Anil K Rustgi Roland M Schmid Roland Rad Maximilian Reichert

Institution:	1. Klinik und Poliklinik für Innere Medizin II, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany;2. Department of Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany;3. Institute of Pathology, Technical University of Munich, Munich, Germany;4. Comparative Experimental Pathology, Technical University of Munich, Munich, Germany;5. German Cancer Consortium, Partner Site Munich, Germany;6. Institute of Stem Cell Research, Helmholtz Center for Health and Environmental Research Munich, Neuherberg, Germany;7. Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, Columbia University, New York, New York

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Keywords:	Cancer-Associated Fibroblasts Myofibroblasts Pancreatic Ductal Adenocarcinoma Extracellular Matrix Proteins 3D"} {"#name":"keyword" "$":{"id":"kwrd0035"} "$$":[{"#name":"text" "_":"3-dimensional α-SMA"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"α-smooth muscle actin CAF"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"cancer-associated fibroblast ECM"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"extracellular matrix EpCAM"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"epithelial cell adhesion molecule ELISA"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"enzyme-linked immunosorbent assay EMT"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"epithelial-mesenchymal transition iCAF"} {"#name":"keyword" "$":{"id":"kwrd0105"} "$$":[{"#name":"text" "_":"inflammatory cancer-associated fibroblast FB"} {"#name":"keyword" "$":{"id":"kwrd0115"} "$$":[{"#name":"text" "_":"fibroblast GFP"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"green fluorescent protein HGF"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"hepatocyte growth factor IF"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"immunofluorescence IHC"} {"#name":"keyword" "$":{"id":"kwrd0155"} "$$":[{"#name":"text" "_":"immunohistochemistry IL"} {"#name":"keyword" "$":{"id":"kwrd0165"} "$$":[{"#name":"text" "_":"interleukin myCAF"} {"#name":"keyword" "$":{"id":"kwrd0175"} "$$":[{"#name":"text" "_":"myofibroblastic cancer-associated fibroblast PanIN"} {"#name":"keyword" "$":{"id":"kwrd0185"} "$$":[{"#name":"text" "_":"pancreatic intraepithelial neoplasia PDAC"} {"#name":"keyword" "$":{"id":"kwrd0195"} "$$":[{"#name":"text" "_":"pancreatic ductal adenocarcinoma Prrx1"} {"#name":"keyword" "$":{"id":"kwrd0205"} "$$":[{"#name":"text" "_":"paired related homeobox 1 PSC"} {"#name":"keyword" "$":{"id":"kwrd0215"} "$$":[{"#name":"text" "_":"pancreatic stellate cell RNA-seq"} {"#name":"keyword" "$":{"id":"kwrd0225"} "$$":[{"#name":"text" "_":"RNA sequencing SPARC"} {"#name":"keyword" "$":{"id":"kwrd0235"} "$$":[{"#name":"text" "_":"secreted protein acidic and cysteine rich TAM"} {"#name":"keyword" "$":{"id":"kwrd0245"} "$$":[{"#name":"text" "_":"tamoxifen TGF"} {"#name":"keyword" "$":{"id":"kwrd0255"} "$$":[{"#name":"text" "_":"transforming growth factor TME"} {"#name":"keyword" "$":{"id":"kwrd0265"} "$$":[{"#name":"text" "_":"tumor microenvironment
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