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Novel Fecal Biomarkers That Precede Clinical Diagnosis of Ulcerative Colitis
Authors:Heather J. Galipeau  Alberto Caminero  Williams Turpin  Miriam Bermudez-Brito  Alba Santiago  Josie Libertucci  Marco Constante  Juan Antonio Raygoza Garay  Gaston Rueda  Sarah Armstrong  Alex Clarizio  Michelle I. Smith  Michael G. Surette  Premysl Bercik
Affiliation:1. Farncombe Family Digestive Health Research Institute, Department of Medicine, McMaster University, Hamilton, Canada;2. Zane Cohen Centre for Digestive Diseases, Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada;3. Division of Gastroenterology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada;1. Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;2. Department of Gastroenterology, the Xianju County People''s Hospital, Taizhou, Zhejiang, China;1. Department of Gastroenterology, Dublin, Ireland;2. Department of Histopathology, Beaumont Hospital, Dublin, Ireland;3. Royal College of Surgeons in Ireland, Dublin, Ireland;1. Department of Medicine, Farncombe Institute, McMaster University, Hamilton, Ontario, Canada;3. Department of Medicine, Columbia University, New York, New York;5. Hospital de Gastroenterologia B. Udaondo, Buenos Aires, Argentina;4. Inova Diagnostics, San Diego, California;1. Massachusetts General Hospital, Clinical and Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts;2. Massachusetts General Hospital, Gastroenterology Unit, Harvard Medical School, Boston, Massachusetts;3. Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;4. Broad Institute of MIT and Harvard, Cambridge Massachusetts, New York, New York;5. Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, New York, New York;6. Sachs’ Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden;7. School of Biological Sciences, Monash University, Clayton, Victoria, Australia;8. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;9. Department of Pediatrics, Orebro University Hospital, Orebro, Sweden;10. Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK;11. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York
Abstract:
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  • Keywords:Ulcerative Colitis  Proteolytic Activity  Microbiome  AGU"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0030"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  axenic-gnotobiotic unit  ANOVA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040a"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  analysis of variance  BHI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  brain-heart infusion  CD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0050"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Crohn’s disease  DADA2"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040aa"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Divisive Amplicon Denoising Algorithm 2  DNase"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0060"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  deoxyribonuclease  GEM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0070"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Genetics  Environmental"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0080"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Microbial  GF"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0090"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  germ free  HC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0100"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  healthy control  H&E"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040ab"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  hematoxylin and eosin  IBD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0110"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  inflammatory bowel disease  IQR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040acc"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  interquartile range  LEfSe"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040add"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Linear discriminant analysis Effect Size  MetaPhlAn"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040aee"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Metagenomic Phylogenetic Analysis 3  PCoA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0120"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  principal coordinate analysis  PERMANOVA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040ac"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  permutational multivariate analysis of variance  PMN"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0130"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  polymorphonuclear  rRNA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040aff"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  ribosomal ribonucleic acid  SD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0040agg"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  standard deviation  UC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0140"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  ulcerative colitis  w/v"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0150"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  weight/volume
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