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The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis
Authors:Hiroki Kobayashi  Krystyna A. Gieniec  Josephine A. Wright  Tongtong Wang  Naoya Asai  Yasuyuki Mizutani  Tadashi Lida  Ryota Ando  Nobumi Suzuki  Tamsin R.M. Lannagan  Jia Q. Ng  Akitoshi Hara  Yukihiro Shiraki  Shinji Mii  Mari Ichinose  Laura Vrbanac  Matthew J. Lawrence  Tarik Sammour  Susan L. Woods
Affiliation:1. Adelaide Medical School, University of Adelaide, Adelaide, Australia;2. South Australian Health and Medical Research Institute, Adelaide, Australia;3. Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan;4. Division of Molecular Pathology, Center for Neurological Disease and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan;5. Department of Molecular Pathology, Graduate School of Medicine, Fujita Health University, Toyoake, Japan;6. Department of Gastroenterology and Hepatology, Nagoya University Graduate School of Medicine, Nagoya, Japan;7. Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;8. Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan;9. Colorectal Unit, Department of Surgery, Royal Adelaide Hospital, Adelaide, Australia;10. Division of Surgical Oncology, Department of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan;11. UCB Pharma, Slough, Berkshire, United Kingdom;12. Translational Vectorology Research Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia;13. Vector and Genome Engineering Facility, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia;14. Military Institute of Hygiene and Epidemiology, The Biological Threats Identification and Countermeasure Centre, Pu?awy, Poland;15. Gene Therapy Research Unit, Sydney Children''s Hospitals Network and Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia;16. Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Australia;17. GenCirq, Inc, San Diego, California;18. Department of Bioengineering, University of California, San Diego, La Jolla, California;19. Precision and Molecular Pathology, Newcastle University, Newcastle Upon Tyne, United Kingdom;20. Intestinal Stem Cell Biology Lab, Wellcome Trust Centre Human Genetics, University of Oxford, Oxford, United Kingdom;21. Herbert Irving Comprehensive Cancer Center, Division of Digestive and Liver Diseases, Department of Medicine, Columbia University, New York, New York;22. Department of Medicine and Irving Cancer Research Center, Columbia University, New York, New York;23. International Center for Cell and Gene Therapy, Fujita Health University, Toyoake, Japan
Abstract:
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