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Regeneration Defects in Yap and Taz Mutant Mouse Livers Are Caused by Bile Duct Disruption and Cholestasis
Authors:Elisabeth Verboven  Iván M Moya  Leticia Sansores-Garcia  Jun Xie  Hanne Hillen  Weronika Kowalczyk  Gerlanda Vella  Stefaan Verhulst  Stéphanie A Castaldo  Ana Algueró-Nadal  Lucia Romanelli  Cristina Mercader-Celma  Natália A Souza  Soheil Soheily  Leen Van Huffel  Thomas Van Brussel  Diether Lambrechts  Tania Roskams  Georg Halder
Institution:1. Vlaams Instituut voor Biotechnologie-Katholieke Universiteit Leuven, Center for Cancer Biology, Department of Oncology, Katholieke Universiteit Leuven, Leuven, Belgium;2. Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Americas, Quito, Ecuador;3. Liver Cell Biology Research Group, Faculty of Medicine and Pharmacy, Vrije Universiteit Brussel, Brussel, Belgium;4. Department of Imaging and Pathology, Translational Cell and Tissue Research, Katholieke Universiteit Leuven and University Hospitals Leuven, Leuven, Belgium;5. Liver and Pancreas Development Unit, de Duve Institute, Université catholique de Louvain, Brussels, Belgium
Abstract:
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  • Keywords:Hippo Pathway  Toxic Injury  Cholangiocytes  Biliary Epithelial Cells  BDL"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"bile duct ligation  BEC"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"biliary epithelial cell  cCasp3"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"cleaved caspase 3  carbon tetrachloride  FXR"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"Farnesoid X receptor  KC"}  {"#name":"keyword"  "$":{"id":"kwrd0085"}  "$$":[{"#name":"text"  "_":"Kupffer cell  MDM"}  {"#name":"keyword"  "$":{"id":"kwrd0095"}  "$$":[{"#name":"text"  "_":"monocyte-derived macrophage  PXR"}  {"#name":"keyword"  "$":{"id":"kwrd0105"}  "$$":[{"#name":"text"  "_":"pregnane X receptor  TBlue"}  {"#name":"keyword"  "$":{"id":"kwrd0115"}  "$$":[{"#name":"text"  "_":"Trypan Blue
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