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DNA methylation and breast cancer-associated variants |
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| Authors: | Ho Peh Joo Dorajoo Rajkumar Ivanković Ivna Ong Seeu Si Khng Alexis Jiaying Tan Benita Kiat-Tee Tan Veronique Kiak Mien Lim Swee Ho Tan Ern Yu Tan Su-Ming Tan Qing Ting Yan Zhiyan Ngeow Joanne Sim Yirong Chan Patrick Chuan Juliana Chen Jia Chan Ching Wan Tang Siau Wei Hartman Mikael Li Jingmei |
| Institution: | 1.Genome Institute of Singapore, Human Genetics, Singapore, Singapore ;2.Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore ;3.Health Systems and Services Research, Duke-NUS Medical School Singapore, Singapore, Singapore ;4.Department of Quantitative Biomedicine, University of Zurich, Zurich, Switzerland ;5.Biomedical Informatics, University Hospital of Zurich, Zurich, Switzerland ;6.Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore, Singapore ;7.Department of Breast Surgery, Singapore General Hospital, Singapore, Singapore ;8.Division of Surgical Oncology, National Cancer Centre Singapore, Singapore, Singapore ;9.KK Breast Department, KK Women’s and Children’s Hospital, Singapore, 229899, Singapore ;10.Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, Singapore ;11.Division of Breast Surgery, Changi General Hospital, Singapore, Singapore ;12.Lee Kong Chian School of Medicine, Nanyang Technology University, Singapore, Singapore ;13.Cancer Genetics Service, National Cancer Centre Singapore, Singapore, Singapore ;14.Oncology Academic Clinical Program, Duke NUS, Singapore, Singapore ;15.Department of Surgery, University Surgical Cluster, National University Hospital, Singapore, Singapore ; |
| Abstract: | Breast Cancer Research and Treatment - A breast cancer polygenic risk score (PRS) comprising 313 common variants reliably predicts disease risk. We examined possible relationships between genetic... |
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