Protein Sub-Visible Particle and Free Radical formation of a Freeze-Dried Monoclonal Antibody Formulation During Dropping |
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| Authors: | Wei-Jie Fang Jia-Wei Liu Hong-Jian Zheng Bin-Bin Shen Xinyu Wang Yi Kong Zhen-Yi Jing Jian-Qing Gao |
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| Affiliation: | 1. Institute of Drug Metabolism and Pharmaceutical Analysis, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China;2. Hangzhou Institute of Innovative Medicine, Zhejiang University, Hangzhou, 310016 China;3. Department of Chemistry, Zhejiang University, Hangzhou, 310013 China;4. The First People''s Hospital of Xiaoshan District, Hangzhou, 311200 China;5. Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058 China |
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| Abstract: | |
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| Keywords: | Aggregation Dropping Electron paramagnetic resonance Free radical g-force Micro-flow imaging Protein sub-visible particle CD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0050" }," $$" :[{" #name" :" text" ," _" :" circular dichroism CE-SDS" },{" #name" :" keyword" ," $" :{" id" :" kwrd0060" }," $$" :[{" #name" :" text" ," _" :" capillary electrophoresis-sodium dodecyl sulfate CHO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0070" }," $$" :[{" #name" :" text" ," _" :" Chinese Hamster Ovary CTPO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0080" }," $$" :[{" #name" :" text" ," _" :" 3-carbamoyl-2,2,5,5-tetramethyl-1-pyrrolidin-yloxy free radical DMPO" },{" #name" :" keyword" ," $" :{" id" :" kwrd0090" }," $$" :[{" #name" :" text" ," _" :" 5,5-dimethyl-1-pyrroline N-oxide EPR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0100" }," $$" :[{" #name" :" text" ," _" :" electron paramagnetic resonance HPLC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0110" }," $$" :[{" #name" :" text" ," _" :" high-performance liquid chromatography IE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0120" }," $$" :[{" #name" :" text" ," _" :" ion exchange mAb" },{" #name" :" keyword" ," $" :{" id" :" kwrd0130" }," $$" :[{" #name" :" text" ," _" :" monoclonal antibody Met" },{" #name" :" keyword" ," $" :{" id" :" kwrd0140" }," $$" :[{" #name" :" text" ," _" :" methionine MFI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0150" }," $$" :[{" #name" :" text" ," _" :" micro-flow imaging RP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0160" }," $$" :[{" #name" :" text" ," _" :" reversed-phase SbVP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0170" }," $$" :[{" #name" :" text" ," _" :" sub-visible particle SE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0180" }," $$" :[{" #name" :" text" ," _" :" size exclusion UV" },{" #name" :" keyword" ," $" :{" id" :" kwrd0190" }," $$" :[{" #name" :" text" ," _" :" ultraviolet |
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