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Protective Role of Tacrolimus,Deleterious Role of Age and Comorbidities in Liver Transplant Recipients With Covid-19: Results From the ELITA/ELTR Multi-center European Study
Authors:Luca S Belli  Constantino Fondevila  Paolo A Cortesi  Sara Conti  Vincent Karam  Rene Adam  Audrey Coilly  Bo Goran Ericzon  Carmelo Loinaz  Valentin Cuervas-Mons  Marco Zambelli  Laura Llado  Fernando Diaz-Fontenla  Federica Invernizzi  Damiano Patrono  Francois Faitot  Sherrie Bhooori  Jacques Pirenne  Christophe Duvoux
Institution:1. Department of Hepatology and Gastroenterology, Niguarda Hospital, Milan, Italy;2. Department of General and Digestive Surgery, Hospital Clínic, Institut d’Investigacion Biomediques August Pi-Sunyer (IDIBAPS) Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), University of Barcelona, Barcelona, Spain;3. Research Centre on Public Health (CESP), University of Milan-Bicocca, Monza, Italy;4. European Liver Transplant Registry, Centre Hépatobiliaire, Assistance Publique-Hôpitaux de Paris, Hôpital Universitaire Paul-Brousse, Paris-Saclay University, Villejuif, France;5. Centre Hepato-Biliaire, Assistance Publique-Hôpitaux de Paris, Hôpital Paul-Brousse, Paris-Sud Saclay University, Villejuif, France;6. Division of Transplantation Surgery, Karolinska University Hospital Huddinge, Stockholm, Sweden;7. Chirugía General, Doce de Octubre Universidad Complutense de Madrid, Madrid, Spain;8. Departimento de Medicina, Hospital Universitario Puerta de Hierro, Universidad Autónoma de Madrid, Madrid, Spain;9. Department of Surgery, “Papa Giovanni XXIII” Hospital, Bergamo, Lombardia, Italy;10. Liver Transplant Unit, Hospital Uniersitari de Bellvitge, Universitat de Barcelona, Barcelona, Spain;11. Unidad de Trasplante Hepático, Hospital General Universitario Gregorio Marañón, Madrid, Spain;12. Division of Gastroenterology and Hepatology, University of Milan, Milan, Italy;13. Liver Transplantation Center, Molinette Hospital, Turin, Italy;14. Service de Chirurgie Hépatobiliaire et Transplantation, Hôpital de Hautepierre, Strasbourg, France;15. Department of Surgery and Oncology, Istituto Nazionale Tumori, Milan, Italy;16. Department of Surgery, University Hospitals Leuven, Leuven, Belgium;17. Service de Transplantation, Hôpitaux Universitaires de Genève, Geneva, Switzerland;18. Liver Unit, Department of Internal Medicine, Hospital Universitari Vall d’Hebron, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Barcelona, Spain;19. Department of Abdominal Surgery and Transplantation, Centre Hospitalier Universitaire Liege, University of Liege, Liege, Belgium;20. Cirugía General y Digestiva, Clínica Universidad de Navarra, Pamplona, Spain;21. Department of General and Hepatobiliary Surgery, Ghent University, Ghent, Belgium;22. Department of General & Digestive Surgery, Instituto de Investigación Sanitaria y Biomédica de Alicante (ISABIAL), Hospital General Universitario de Alicante, Alicante, Spain;23. Department of Surgery, Antwerp University Hospital, Antwerp University, Edegem, Belgium;24. Service d’Hépato-Gastroentérologie, Hôpital de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France;25. Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, the Netherlands;26. Liver and Multi-organ Transplantation, Sant’Orsola-Malpighi Hospital, University of Bologna, Bologna, Italy;27. General Surgery and Abdominal Transplantation Unit, Niguarda-Cà Granda Hospital, and School of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy;28. Department of Surgery, Erasmus MC, University Medical Center Rotterdam, the Netherlands;29. Department of Hepatology and Medical Liver Transplant Unit, Henri Mondor Hospital Assistance Publique-Hôpitaux de Paris, Paris-Est University, Creteil, France
Abstract:
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  • Keywords:COVID-19  Liver transplantation  Outcome  Tacrolimus  ALT"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"alanine aminotransferase  CI"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"confidence interval  CNI"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"calcineurin inhibitor  COVID-19"}  {"#name":"keyword"  "$":{"id":"kwrd0065"}  "$$":[{"#name":"text"  "_":"coronavirus disease 2019  CsA"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"cyclosporine A  ELITA"}  {"#name":"keyword"  "$":{"id":"kwrd0085"}  "$$":[{"#name":"text"  "_":"European Liver Transplantation Association  ELTR"}  {"#name":"keyword"  "$":{"id":"kwrd0095"}  "$$":[{"#name":"text"  "_":"European Liver Transplant Registry  ICU"}  {"#name":"keyword"  "$":{"id":"kwrd0105"}  "$$":[{"#name":"text"  "_":"intensive care unit  LT"}  {"#name":"keyword"  "$":{"id":"kwrd0115"}  "$$":[{"#name":"text"  "_":"liver transplant  MMF"}  {"#name":"keyword"  "$":{"id":"kwrd0125"}  "$$":[{"#name":"text"  "_":"mycophenolate mofetil  mTOR"}  {"#name":"keyword"  "$":{"id":"kwrd0135"}  "$$":[{"#name":"text"  "_":"mammalian target of rapamycin  SARS-CoV2"}  {"#name":"keyword"  "$":{"id":"kwrd0145"}  "$$":[{"#name":"text"  "_":"severe acute respiratory syndrome coronavirus 2  TAC"}  {"#name":"keyword"  "$":{"id":"kwrd0155"}  "$$":[{"#name":"text"  "_":"tacrolimus
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