MicroRNA-211 Modulates the DUSP6-ERK5 Signaling Axis to Promote BRAFV600E-Driven Melanoma Growth In Vivo and BRAF/MEK Inhibitor Resistance |
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| Authors: | Bongyong Lee Anupama Sahoo Junko Sawada John Marchica Sanjay Sahoo Fabiana I.A.L. Layng Darren Finlay Joseph Mazar Piyush Joshi Masanobu Komatsu Kristiina Vuori Petrus R. de Jong Animesh Ray Ranjan J. Perera |
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| Affiliation: | 1. Department of Oncology, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA;2. Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida, USA;3. Department of Cancer and Blood Disorders Institute, Johns Hopkins All Children’s Hospital, St. Petersburg, Florida, USA;4. Sanford Burnham Prebys Medical Discovery Institute, NCI-Designated Cancer Center, La Jolla, California, USA;5. Keck Graduate Institute, Claremont, California, USA;6. Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California, USA |
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| Abstract: | |
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| Keywords: | A375/vo" },{" #name" :" keyword" ," $" :{" id" :" kwrd0015" }," $$" :[{" #name" :" text" ," _" :" vector-only control cells DUSP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0025" }," $$" :[{" #name" :" text" ," _" :" dual-specificity phosphatase ERK" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" extracellular signal–regulated kinase FDR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" false discovery rate half maximal inhibitory concentration MEK" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" MAPK/ERK kinase miR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" microRNA pERK5" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" phospho-ERK5 |
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