Single-Cell Transcriptional Survey of Ileal-Anal Pouch Immune Cells From Ulcerative Colitis Patients |
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| Authors: | Joseph C. Devlin Jordan Axelrad Ashley M. Hine Shannon Chang Suparna Sarkar Jian-Da Lin Kelly V. Ruggles David Hudesman Ken Cadwell P’ng Loke |
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| Affiliation: | 1. Department of Microbiology;2. Vilcek Institute of Graduate Biomedical Sciences;3. Institute of Systems Genetics;4. Division of Gastroenterology and Hepatology, Department of Medicine;5. Department of Pathology;6. Skirball Institute of Biomedical Medicine;7. Division of Translational Medicine, Department of Medicine, New York University Grossman School of Medicine, New York, New York;8. Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;9. Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan;1. Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;2. Department of Gastroenterology, the Xianju County People''s Hospital, Taizhou, Zhejiang, China;1. Massachusetts General Hospital, Clinical and Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts;2. Massachusetts General Hospital, Gastroenterology Unit, Harvard Medical School, Boston, Massachusetts;3. Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;4. Broad Institute of MIT and Harvard, Cambridge Massachusetts, New York, New York;5. Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, New York, New York;6. Sachs’ Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden;7. School of Biological Sciences, Monash University, Clayton, Victoria, Australia;8. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;9. Department of Pediatrics, Orebro University Hospital, Orebro, Sweden;10. Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK;11. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York;1. Department of Medicine, Division of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee;2. Program in Cancer Biology, Vanderbilt University, Nashville, Tennessee;3. Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee;4. Department of Radiation Oncology, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, Pennsylvania;5. Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children''s Hospital Medical Center, Cincinnati, Ohio;6. Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio;7. Sheba Medical Center, Tel Hashomer, affiliated with the Tel Aviv University, Tel Aviv, Israel;8. School of Medicine, Southern Illinois University, Springfield, Illinois;9. Department of Biology, University of Oregon, Eugene, Oregon;10. Institute of Molecular Biology, University of Oregon, Eugene, Oregon;11. Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee;12. Department of Pathology, Duke University School of Medicine, Durham, North Carolina;13. Department of Public Health Sciences and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida;14. Veterans Affairs Tennessee Valley Health Care System, Nashville, Tennessee;15. Vanderbilt Ingram Cancer Center, Nashville, Tennessee;16. Connecticut Children''s Medical Center, Hartford, Connecticut;1. The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York;2. Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York;3. Department of Pathology, Icahn School of Medicine at Mount Sinai, New York;4. Precision Immunology Institute at the Icahn School of Medicine at Mount Sinai, New York;5. Division of Gastroenterology, Hepatology and Nutrition, University of Pittsburgh, Pittsburgh, Pennsylvania;6. Zane Cohen Centre for Digestive Diseases, Division of Gastroenterology, Mount Sinai Hospital, University of Toronto, Ontario, Canada, Toronto, Ontario, Canada;7. Crohns and Colitis Center of New Jersey, Division of Gastroenterology and Hepatology, Department of Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, New Jersey;8. Research Centre, Montreal Heart Institute, Montréal, Quebec, Canada;9. Faculty of Medicine, Université de Montréal, Montréal, Quebec, Canada;10. Department of Health Sciences, University of Chicago, Chicago, Illinois;11. F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, California |
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| Abstract: | |
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| Keywords: | Inflammatory Bowel Disease Mucosal Immunology Single Cell RNA-Seq Inflammation CD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0035" }," $$" :[{" #name" :" text" ," _" :" Crohn’s disease DC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0045" }," $$" :[{" #name" :" text" ," _" :" dendritic cell DE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" differential expression FAP" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" familial adenomatous polyposis FDA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" Food and Drug Administration IBD" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" inflammatory bowel disease IL" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" interleukin IPAA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" ileal pouch–anal anastomosis ISCORE" },{" #name" :" keyword" ," $" :{" id" :" kwrd0115" }," $$" :[{" #name" :" text" ," _" :" composite inflammation score PCA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0125" }," $$" :[{" #name" :" text" ," _" :" principal component analysis PDAI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0135" }," $$" :[{" #name" :" text" ," _" :" pouchitis disease activity index scRNA-seq" },{" #name" :" keyword" ," $" :{" id" :" kwrd0145" }," $$" :[{" #name" :" text" ," _" :" single-cell RNA sequencing TNF" },{" #name" :" keyword" ," $" :{" id" :" kwrd0155" }," $$" :[{" #name" :" text" ," _" :" tumor necrosis factor UC" },{" #name" :" keyword" ," $" :{" id" :" kwrd0165" }," $$" :[{" #name" :" text" ," _" :" ulcerative colitis |
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