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The Redox Modulating Sonlicromanol Active Metabolite KH176m and the Antioxidant MPG Protect Against Short-Duration Cardiac Ischemia-Reperfusion Injury |
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| Authors: | Xiao Yang Yim Karen Zhang Hong Bakker Diane Nederlof Rianne Smeitink Jan A. M. Renkema Herma Hollmann Markus W. Weber Nina C. Zuurbier Coert J. |
| Affiliation: | 1.Laboratory of Experimental Intensive Care and Anesthesiology, Department of Anesthesiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, University of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands ;2.Institut für Herz- und Kreislaufphysiologie, Heinrich- Heine- Universit?t Düsseldorf, Universit?tsstra?e 1, Düsseldorf, Germany ;3.Khondrion, Philips van Leydenlaan 15, Nijmegen, The Netherlands ;4.Department of Anesthesiology, Amsterdam UMC, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands ; |
| Abstract: | Cardiovascular Drugs and Therapy - Sonlicromanol is a phase IIB clinical stage compound developed for treatment of mitochondrial diseases. Its active component, KH176m, functions as an antioxidant,... |
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