Physicomechanical,optical, and antifungal properties of polymethyl methacrylate modified with metal methacrylate monomers |
| |
| Authors: | Andressa da Silva Barboza Laura K. Fang Juliana S. Ribeiro Carlos E. Cuevas-Suárez Rafael R. Moraes Rafael G. Lund |
| |
| Affiliation: | 1. PhD candidate, Graduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas (UFPEL), Pelotas-RS, Brazil;2. MSc candidate, Graduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas (UFPEL), Pelotas-RS, Brazil;3. PhD candidate, Graduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas (UFPEL), Pelotas-RS, Brazil;1. Researcher assistant, Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, Ann Arbor, Mich;4. Professor, Dental Materials Laboratory, Academic Area of Dentistry, Autonomous University of Hidalgo State, Pachuca, Mexico;5. Associate professor, Graduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas (UFPEL), Pelotas, Rio Grande do Sul, Brazil;6. Associate professor, Graduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas (UFPEL), Pelotas, Rio Grande do Sul, Brazil |
| |
| Abstract: | Statement of problemThe high recurrence rates of denture stomatitis may be associated with the resistance of biofilms to therapeutics. Therefore, methods that provide biomaterials with antifungal properties are an attractive solution to improving microbial control.PurposeThe purpose of this in vitro study was to modify conventional polymethyl methacrylate (PMMA) through the incorporation of metal methacrylate monomers and to evaluate the physicomechanical and optical properties and antifungal activity of the modified materials.Material and methodsExperimental denture base acrylic resins were fabricated through the addition of zirconium methacrylate (ZM), tin methacrylate (TM), and di-n-butyldimethacrylate-tin (DNBMT) to the liquid of a commercially available denture base PMMA resin. Unmodified PMMA resin was used as the control. The degree of conversion of the materials was tested through Fourier transform infrared spectroscopy (n=3). A digital spectrophotometer was used to assess the color change of the modified materials (n=8). Differences in Knoop hardness and roughness between experimental groups were also evaluated (n=8). A biofilm accumulation test with Candida albicans (ATCC 62342) (n=4) was performed for 5 days in Sabouraud broth culture supplemented with 10% sucrose. Data were subjected to analysis of variance and the post hoc Tukey honestly significant difference test (α=.05).ResultsThe degree of conversion and color-change values of the experimental materials were statistically similar to those of the control (P=.593). The incorporation of DNBMT significantly increased the hardness of the modified material (P=.014). The ZM, TM, and DNBMT groups had higher antifungal activity against C. albicans (P=.001) and lower roughness than the control group (control 0.65 ±0.05 μm; ZM 0.34 ±0.09 μm, TM 0.34 ±0.11 μm, and DNBMT 0.41 ±0.08 μm).ConclusionsThe metal-containing methacrylate monomers provided antifungal action to the modified materials without affecting the physicomechanical or optical properties of the denture base resin. ZM, TM, and DNBMT are potential reactive agents for the fabrication of PMMA denture base resins with antifungal properties. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
