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Proton Pump Inhibitors Reduce Duodenal Eosinophilia,Mast Cells,and Permeability in Patients With Functional Dyspepsia
Authors:Lucas Wauters  Matthias Ceulemans  Dennis Frings  Maarten Lambaerts  Alison Accarie  Joran Toth  Raf Mols  Patrick Augustijns  Gert De Hertogh  Lukas Van Oudenhove  Jan Tack  Tim Vanuytsel
Institution:1. Department of Gastroenterology and Hepatology, University Hospitals Leuven, Leuven, Belgium;2. Translational Research in Gastrointestinal Disorders, Department of Chronic Diseases, Metabolism and Ageing, Katholieke Universiteit Leuven, Leuven, Belgium;3. Drug Delivery and Disposition, Katholieke Universiteit Leuven, Leuven, Belgium;4. Department of Pathology, University Hospitals Leuven, Leuven, Belgium;1. Massachusetts General Hospital, Clinical and Translational Epidemiology Unit, Mongan Institute, Boston, Massachusetts;2. Massachusetts General Hospital, Gastroenterology Unit, Harvard Medical School, Boston, Massachusetts;3. Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden;4. Broad Institute of MIT and Harvard, Cambridge Massachusetts, New York, New York;5. Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, New York, New York;6. Sachs’ Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden;7. School of Biological Sciences, Monash University, Clayton, Victoria, Australia;8. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;9. Department of Pediatrics, Orebro University Hospital, Orebro, Sweden;10. Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, UK;11. Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York;1. Department of Gastroenterology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China;2. Department of Gastroenterology, the Xianju County People''s Hospital, Taizhou, Zhejiang, China
Abstract:
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  • Keywords:Functional Dyspepsia  Proton Pump Inhibitor  Inflammation  Permeability  EPS"}  {"#name":"keyword"  "$":{"id":"kwrd0035"}  "$$":[{"#name":"text"  "_":"epigastric pain syndrome  FD4"}  {"#name":"keyword"  "$":{"id":"kwrd0045"}  "$$":[{"#name":"text"  "_":"fluorescein isothiocyanate-labelled 4kDa dextran  FD"}  {"#name":"keyword"  "$":{"id":"kwrd0055"}  "$$":[{"#name":"text"  "_":"functional dyspepsia  GI"}  {"#name":"keyword"  "$":{"id":"kwrd0065"}  "$$":[{"#name":"text"  "_":"gastrointestinal  HV"}  {"#name":"keyword"  "$":{"id":"kwrd0075"}  "$$":[{"#name":"text"  "_":"healthy volunteer  PDS"}  {"#name":"keyword"  "$":{"id":"kwrd0085"}  "$$":[{"#name":"text"  "_":"postprandial distress syndrome  PPI"}  {"#name":"keyword"  "$":{"id":"kwrd0095"}  "$$":[{"#name":"text"  "_":"proton pump inhibitor  PSS"}  {"#name":"keyword"  "$":{"id":"kwrd0105"}  "$$":[{"#name":"text"  "_":"Perceived Stress Scale
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