Curcumin Encapsulated Casein Nanoparticles: Enhanced Bioavailability and Anticancer Efficacy |
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Authors: | K.C. Barick Avanika Tripathi Bijaideep Dutta Sandeep B. Shelar P.A. Hassan |
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Affiliation: | 1. Chemistry Division, Bhabha Atomic Research Centre, Trombay, Mumbai, 400 085;2. Homi Bhabha National Institute, Anushaktinagar, Mumbai, 400 094;3. Department of Pharmacy, Banasthali Vidyapith, Rajasthan, 304 022 |
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Abstract: | The poor water solubility and bioactivity of drugs can be potentially improved by using suitable nanocarriers. Herein, an economically viable methodology is developed for encapsulation of hydrophobic anticancer agent, curcumin in casein nanoparticles (CasNPs). The successful encapsulation of curcumin was evident from the structural, thermal and spectroscopic analysis of curcumin encapsulated CasNPs (Cur-CasNPs). The CasNPs and Cur-CasNPs samples were lyophilized for their long-term stability and lyophilized powders are found to be stable for more than 6 months at 4–8 °C. From DLS studies, it has been observed that the variation in average size of drug formulations before and after reconstitution were less than 5%. Further, it shows good water-dispersibility, enhanced bioavailability and pH dependent charge conversal feature. Cur-CasNPs showed pH dependent release characteristics with higher at mild acidic environment and enhanced toxicity towards cancer cells (MCF-7) as compared to normal cells (CHO). Moreover, the CasNPs are non-toxic in nature and the developed nanoformulation of drug exhibits substantial cellular internalization and enhanced toxicity towards MCF-7 cells over pure drug, indicating their potential applications. |
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Keywords: | Protein Nanoparticles Drug delivery system Cancer chemotherapy Toxicity Curcumin Casein |
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