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Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis

Authors:	Alain P Gobert Olivier Boutaud Mohammad Asim Irene A Zagol-Ikapitte Alberto G Delgado Yvonne L Latour Jordan L Finley Kshipra Singh Thomas G Verriere Margaret M Allaman Daniel P Barry Kara M McNamara Johanna C Sierra Venkataraman Amarnath Mohammed N Tantawy Diane Bimczok M Blanca Piazuelo M Kay Washington Keith T Wilson

Institution:	1. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;2. Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee;3. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee;4. Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee;5. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee;6. Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee;7. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee;8. Department of Microbiology and Immunology, Montana State University, Bozeman, Montana;9. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee;10. Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee;1. Westmead Hospital, Department of Gastroenterology and Hepatology;2. Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia;1. Department of Internal Medicine and Division of Gastroenterology and Hepatology;2. Department of Anatomic Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota;1. Department of Internal Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, Illinois;2. MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, Illinois;3. Department of Internal Medicine, University of Chicago, Chicago, Illinois

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Keywords:	Stomach Cancer Colorectal cancer Electrophiles Chemoprevention 4-ONE"} {"#name":"keyword" "$":{"id":"kwrd0035"} "$$":[{"#name":"text" "_":"4-oxo-2-nonenal AOM"} {"#name":"keyword" "$":{"id":"kwrd0045"} "$$":[{"#name":"text" "_":"azoxymethane CAC"} {"#name":"keyword" "$":{"id":"kwrd0055"} "$$":[{"#name":"text" "_":"colitis-associated carcinoma CD"} {"#name":"keyword" "$":{"id":"kwrd0065"} "$$":[{"#name":"text" "_":"Crohn’s disease CRC"} {"#name":"keyword" "$":{"id":"kwrd0075"} "$$":[{"#name":"text" "_":"colorectal cancer DSS"} {"#name":"keyword" "$":{"id":"kwrd0085"} "$$":[{"#name":"text" "_":"dextran sulfate sodium EtHOBA"} {"#name":"keyword" "$":{"id":"kwrd0095"} "$$":[{"#name":"text" "_":"5-ethyl-2-hydroxybenzylamine 2-deoxy-2-[fluorine-18]sodium fluoride GEC"} {"#name":"keyword" "$":{"id":"kwrd0125"} "$$":[{"#name":"text" "_":"gastric epithelial cells HGD"} {"#name":"keyword" "$":{"id":"kwrd0135"} "$$":[{"#name":"text" "_":"high-grade dysplasia IBD"} {"#name":"keyword" "$":{"id":"kwrd0145"} "$$":[{"#name":"text" "_":"inflammatory bowel disease IHC"} {"#name":"keyword" "$":{"id":"kwrd0155"} "$$":[{"#name":"text" "_":"immunohistochemistry IL"} {"#name":"keyword" "$":{"id":"kwrd0165"} "$$":[{"#name":"text" "_":"interleukin IM"} {"#name":"keyword" "$":{"id":"kwrd0175"} "$$":[{"#name":"text" "_":"intestinal metaplasia IMC"} {"#name":"keyword" "$":{"id":"kwrd0185"} "$$":[{"#name":"text" "_":"intramucosal carcinoma INS-GAS"} {"#name":"keyword" "$":{"id":"kwrd0195"} "$$":[{"#name":"text" "_":"insulin-gastrin isoLG"} {"#name":"keyword" "$":{"id":"kwrd0205"} "$$":[{"#name":"text" "_":"isolevuglandin isoLG-lysyl"} {"#name":"keyword" "$":{"id":"kwrd0215"} "$$":[{"#name":"text" "_":"adducts of isolevuglandins to lysine LC/ESI/MS/MS"} {"#name":"keyword" "$":{"id":"kwrd0225"} "$$":[{"#name":"text" "_":"liquid chromatography electrospray ionization tandem mass spectrometry LGD"} {"#name":"keyword" "$":{"id":"kwrd0235"} "$$":[{"#name":"text" "_":"low-grade dysplasia MAG"} {"#name":"keyword" "$":{"id":"kwrd0245"} "$$":[{"#name":"text" "_":"multifocal atrophic gastritis MDA"} {"#name":"keyword" "$":{"id":"kwrd0255"} "$$":[{"#name":"text" "_":"malondialdehyde NAG"} {"#name":"keyword" "$":{"id":"kwrd0265"} "$$":[{"#name":"text" "_":"nonatrophic gastritis NSAID"} {"#name":"keyword" "$":{"id":"kwrd0275"} "$$":[{"#name":"text" "_":"nonsteroidal anti-inflammatory drug PET/CT"} {"#name":"keyword" "$":{"id":"kwrd0285"} "$$":[{"#name":"text" "_":"positron emission tomography/computed tomography PGHS2"} {"#name":"keyword" "$":{"id":"kwrd0295"} "$$":[{"#name":"text" "_":"prostaglandin G/H synthase 2 pH2AX"} {"#name":"keyword" "$":{"id":"kwrd0305"} "$$":[{"#name":"text" "_":"phosphorylation of serine 139 of H2A histone family member X SNP"} {"#name":"keyword" "$":{"id":"kwrd0315"} "$$":[{"#name":"text" "_":"single nucleotide polymorphisms TMA"} {"#name":"keyword" "$":{"id":"kwrd0325"} "$$":[{"#name":"text" "_":"tissue microarray TNF"} {"#name":"keyword" "$":{"id":"kwrd0335"} "$$":[{"#name":"text" "_":"tumor necrosis factor UC"} {"#name":"keyword" "$":{"id":"kwrd0345"} "$$":[{"#name":"text" "_":"ulcerative colitis VAF"} {"#name":"keyword" "$":{"id":"kwrd0355"} "$$":[{"#name":"text" "_":"variant allele frequency WES"} {"#name":"keyword" "$":{"id":"kwrd0365"} "$$":[{"#name":"text" "_":"whole-exome sequencing
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