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Dicarbonyl Electrophiles Mediate Inflammation-Induced Gastrointestinal Carcinogenesis
Authors:Alain P. Gobert  Olivier Boutaud  Mohammad Asim  Irene A. Zagol-Ikapitte  Alberto G. Delgado  Yvonne L. Latour  Jordan L. Finley  Kshipra Singh  Thomas G. Verriere  Margaret M. Allaman  Daniel P. Barry  Kara M. McNamara  Johanna C. Sierra  Venkataraman Amarnath  Mohammed N. Tantawy  Diane Bimczok  M. Blanca Piazuelo  M. Kay Washington  Keith T. Wilson
Affiliation:1. Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee;2. Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee;3. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee;4. Department of Biochemistry, Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee;5. Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee;6. Vanderbilt University Institute of Imaging Science, Vanderbilt University Medical Center, Nashville, Tennessee;7. Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, Tennessee;8. Department of Microbiology and Immunology, Montana State University, Bozeman, Montana;9. Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee;10. Veterans Affairs Tennessee Valley Healthcare System, Nashville, Tennessee;1. Westmead Hospital, Department of Gastroenterology and Hepatology;2. Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia;1. Department of Internal Medicine and Division of Gastroenterology and Hepatology;2. Department of Anatomic Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota;1. Department of Internal Medicine, Section of Gastroenterology, Hepatology and Nutrition, University of Chicago, Chicago, Illinois;2. MacLean Center for Clinical Medical Ethics, University of Chicago, Chicago, Illinois;3. Department of Internal Medicine, University of Chicago, Chicago, Illinois
Abstract:
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  • Keywords:Stomach Cancer  Colorectal cancer  Electrophiles  Chemoprevention  4-ONE"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0035"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  4-oxo-2-nonenal  AOM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  azoxymethane  CAC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  colitis-associated carcinoma  CD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Crohn’s disease  CRC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0075"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  colorectal cancer  DSS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  dextran sulfate sodium  EtHOBA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  5-ethyl-2-hydroxybenzylamine  2-deoxy-2-[fluorine-18]sodium fluoride  GEC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0125"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  gastric epithelial cells  HGD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0135"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  high-grade dysplasia  IBD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0145"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  inflammatory bowel disease  IHC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0155"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  immunohistochemistry  IL"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0165"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  interleukin  IM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0175"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  intestinal metaplasia  IMC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0185"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  intramucosal carcinoma  INS-GAS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0195"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  insulin-gastrin  isoLG"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0205"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  isolevuglandin  isoLG-lysyl"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0215"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  adducts of isolevuglandins to lysine  LC/ESI/MS/MS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0225"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  liquid chromatography electrospray ionization tandem mass spectrometry  LGD"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0235"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  low-grade dysplasia  MAG"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0245"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  multifocal atrophic gastritis  MDA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0255"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  malondialdehyde  NAG"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0265"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  nonatrophic gastritis  NSAID"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0275"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  nonsteroidal anti-inflammatory drug  PET/CT"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0285"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  positron emission tomography/computed tomography  PGHS2"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0295"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  prostaglandin G/H synthase 2  pH2AX"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0305"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  phosphorylation of serine 139 of H2A histone family member X  SNP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0315"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  single nucleotide polymorphisms  TMA"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0325"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  tissue microarray  TNF"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0335"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  tumor necrosis factor  UC"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0345"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  ulcerative colitis  VAF"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0355"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  variant allele frequency  WES"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kwrd0365"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  whole-exome sequencing
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