吸毒并肺结核患者细胞免疫学特点

目的 研究吸毒并患肺结核患者的细胞免疫学特点.方法 选取同期在本院收治的初诊吸毒并患肺结核患者和初诊非吸毒患肺结核患者各60例,分别作为观察组和对照组,确诊后3 d内清晨空腹抽取外周静脉血,用流式细胞仪检测CD3 、CD3 /CD4 、CD3 /CD8 T淋巴细胞亚群和NK细胞亚群比例,计算CD4 /CD8 比值,分析两组患者免疫学检测结果的差异.结果 观察组患者外周血CD3 、CD3 /CD4 T淋巴细胞和NK细胞比例均低于对照组(P=0.037,0.028,0.015),CD4 /CD8 比值亦较对照组降低(P=0.021);两组患者结核病类型分布和外周血CD3 /CD8 T淋巴细胞亚群比例无显著差异(P=0.053,0.85).结论 吸毒并肺结核患者细胞免疫功能下降,是吸毒人群易患肺结核以及治疗难度增大的原因之一.

Cellular immunity characteristics in drug abusers with pulmonary tuberculosis

Objective To explore the characteristics of cellular immunity in drug abusers with pulmonary tuberculosis.Methods Sixty drug abusers with pulmonary tuberculosis and 60 non-drug abusers with pulmonary tuberculosis(control)were enrolled in this study.Three days after establishment of a definite diagnosis,peripheral blood was taken from the patients for lymphocyte subgroup(CD3 ,CD3 /CD4 ,CD3 /CD8 T lymphocyte subgroups and NK cells)examination by flow cytometry,and the CD4 /CD8 ratio was calculated.The difference of cellular immunity between the drug abusers and control group was analyzed statistically.Results CD3 and CD3 /CD4 T lymphocytes subgroups and NK cells of the drug abusers were significantly lower than those of the control patients(P=0.037,0.028 and 0.015),and the former patients had also significantly lower CD4 /CD8 ratio(P=0.021).The pulmonary tuberculosis types and CD3 /CD8 T lymphocyte subgroup were not significant different between the two groups(P=0.053 and 0.85).Conclusion Drug abuse might depress cellular immunity in patients with pulmonary tuberculosis,which further complicate the treatment of this disease.