| 恒定磁场对大鼠心肌缺血／再灌注损伤和无复流面积的影响 |
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| 引用本文： | 李敬霞,程何祥,牟翔,张荣庆,栾荣华,王海昌.恒定磁场对大鼠心肌缺血／再灌注损伤和无复流面积的影响[J].第四军医大学学报,2009,30(1):80-82. |
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| 作者姓名： | 李敬霞 程何祥 牟翔 张荣庆 栾荣华 王海昌 |
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| 作者单位： | 李敬霞,程何祥,张荣庆,栾荣华,王海昌,LI Jing-Xia,CHENG He-Xiang,ZHANG Rong-Qing,LUAN Rong-Hua,WANG Hai-Chang(第四军医大学西京医院,心血管内科,陕西,西安,710033);牟翔,MU Xiang(第四军医大学西京医院,理疗科,陕西,西安,710033)
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| 基金项目： | 第四军医大学西京医院临床高新技术项目 |
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| 摘 要： | 目的：观察恒定磁场干预对大鼠心肌缺血／再灌注损伤和无复流面积的影响．方法：将24只雄性sD大鼠随机分为4组：假手术组、缺血／再灌注组、50mT恒定磁场＋缺血／再灌注组及100mT恒定磁场＋缺血／再灌注组，每组6只．大鼠麻醉开胸，结扎冠状动脉前降支40min，再灌注4h．采用硫黄素染色评估缺血心肌再灌注后的无复流面积，Evan’s蓝和氯化三苯基氮四唑（TTC）染色法测定心肌梗死范围；全自动生化分析仪测定血清肌酸激酶（CK）的水平，微粒子化学发光法测定血清肌钙蛋白I（cTnI）的水平．结果：50mT及100mT恒定磁场干预组的心肌梗死面积和无复流面积显著小于缺血／再灌注组（P〈0．05）．缺血／再灌注组大鼠血清CK和cTnI的水平与假手术组比较显著升高（P〈0．05）；而不同强度的恒定磁场干预＋缺血／再灌注组血清CK和cTnI的水平与缺血／再灌注组比较显著降低（P〈0．05）．结论：恒定磁场干预可减轻缺血／再灌注所致大鼠心肌的损伤和无复流面积．
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| 关 键 词： | 恒定磁场 心肌缺血 再灌注损伤 细胞凋亡 |
Effect of constant magnetic field on myocardial ischemia-reperfusion injury and no-reflow area in rats |
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| LI Jing-Xia,CHENG He-Xiang,MU Xiang,ZHANG Rong-Qing,LUAN Rong-Hua,WANG Hai-Chang.Effect of constant magnetic field on myocardial ischemia-reperfusion injury and no-reflow area in rats[J].Journal of the Fourth Military Medical University,2009,30(1):80-82. |
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| Authors: | LI Jing-Xia CHENG He-Xiang MU Xiang ZHANG Rong-Qing LUAN Rong-Hua WANG Hai-Chang |
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| Institution: | LI Jing-Xia1,CHENG He-Xiang1,MU Xiang2,ZHANG Rong-Qing1,LUAN Rong-Hua1,WANG Hai-Chang11Department of Cardiovasology,2Department of Physiotherapy,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China |
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| Abstract: | AIM:To investigate the effect of constant magnetic field (CMF) on myocardial ischemia/reperfusion injury (IRI) and no-reflow area in rats.METHODS:Twenty-four male Sprague-Dawley rats were randomly divided into 4 groups: sham operation group, IRI group, 50 mT CMF intervention group and 100 mT CMF intervention group, with 6 in each group. The rats were anesthetized and then underwent 40 min of myocardial ischemia and 4 h of reperfusion. Size of no-reflow area was determined by thioflavin-S. The infarct size w... |
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| Keywords: | constant magnetic field myocardial ischemia reperfusion injury no-reflow |
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