冠心病患者血浆OLAB、BNP和CRP水平变化分析

检测冠心病患者血浆OLAB、BNP和CRP水平变化, 探讨冠心病发病机制及不稳定性心绞痛(UAP)治疗前后对其影响.用RIA和ELISA法对124例冠心病患者和30名对照者血浆中的OLAB、BNP和CRP水平变化及相关性进行研究, 同时对48例UAP经皮冠状动脉形成术(PTCA)治疗前、后对上述三项指标的变化进行分析; 结果表明冠心病患者与对照组比较BNP水平有显著性差异(P＜0.01),尤其是AMI和UAP组比SAP组升高更明显; CRP水平比对照组明显增高(P＜0.05),特别是不稳定性心绞痛和AMI组升高明显(P＜0.05);AMI组血浆OLAB水平明显高于正常和其他两组, OLAB、BNP和CRP三项在UAP组中治疗前后比较差异显著(P＜0.01).总之,OLAB、BNP和CRP参与了冠心病的发病过程, 并可预测心肌梗死患者远期心功能恢复的情况, UAP组经PTCA支架术后, 三项指标均明显降低, 可作为疗效观察的一个重要参数, OLAB参与了冠状动脉粥样硬化的全过程及AMI的发病始末.

Analysis of OLAB, BNP and CRP Levels in the Plasma of Patients with Cardiovascular Disease

To explore the mechanism of coronary heart disease and the effect of therapy on unstable angina pectoris(UAP) OLAB, brain natriuretic peptide(BNP) and supersensitive C reaction protein(CRP) levels in the plasma of patients with coronary heart disease were detected.The OLAB, BNP and CRP levels and their correlations in the plasma of 124 patients with coronary heart disease and 30 controls were determined by chemiluminescence and ELISA technique, respectively.The OLAB, BNP and CRP levels of 48 UAP patients after PTCA were also analyzed.The BNP and CRP levels of patients with coronary heart disease, especially acute myocardial infarction(AMI) and UAP patients to stable angina pectoris(SAP) patients were higher than those of controls(P<0.01).The OLAB levels in AMI patients was higher than UAP, SAP and controls(P<0.05).There was a significant difference of OLAB, BNP and CRP levels in UAP patients before and after PTCA therapy(P<0.05).OLAB, BNP and CRP, which is involved in the developing procedure of coronary heart disease, may be used to predict the long-term cardiac function recover.OLAB,BNP and CRP levels in UAP patients were decreased significantly after PTCA and may also be considered as the therapy effect observing markers.OLAB takes part in the whole procedure of coronary atherosclerosis and the occurrence and ending of AMI.