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Fungicidal monoclonal antibody C7 binds to Candida albicans Als3 |
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| Authors: | Brena Sonia Omaetxebarría Miren J Elguezabal Natalia Cabezas Jonathan Moragues María D Pontón José |
| Affiliation: | Departamento de Inmunología, Microbiología y Parasitología, Facultad de Medicina y Odontología, Universidad del País Vasco, Apartado 699, E-48080 Bilbao, Vizcaya, Spain. |
| Abstract: | Monoclonal antibody (MAb) C7 reacted with a >200-kDa component from the Candida albicans cell wall identified by matrix-assisted laser desorption ionization-time-of-flight mass spectrometry as Als3. It also bound the recombinant N terminus of Als3. Binding of MAb C7 to Als3 may explain the biological activities exerted by the MAb on C. albicans. |
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