左氧氟沙星治疗肺结核的临床研究

目的评价左氧氟沙星对肺结核的疗效、适宜剂量以及在我国应用的前景。方法将91例初治茵阳肺结核患随机分为治疗组和对照组进行短程化疗。结果治疗组和对照组2个月痰茵阴转率分别为91．5％和84．1％；满疗程痰茵阴转率分别为97．9％和97．7％。胸部X线改善，治疗组和对照组病灶吸收率分别为97．8％和97．7％，两组分别有58．8％和47．1％的空洞闲合。两组不良反应发生率治疗组与对照组分别为13．2％和7．8％。结论左氧氟沙星具有较好的抗结核活性和较高的生物利用度，对巨噬细胞内、外的结核茵有很好的杀灭、抑制作用，且使用安全。

Clinical Study on the Effect of Levotloxacin in Treating Pulmonary Tuberculosis

Objective To valuate the antituberculosis effect, suitable dose and application prospect of Levofloxacin in China.Methods 91 patients with new smear positive pulmonary tuberculosis were randomly divided into the treatment group and the controlgroup to give chemotherapy.Results The aputum negative conversion at the end of 2 months in the treatment group and the control group were 91.50% and 84.1% respectively,and at the end of chemotherapy 97.9% and 97.7%. Chest radiography showed remarkable improvement.The resolution of pulmonary lesions in the treatment group and the control group accounted for 97.8% and 97. 7% respectively,with cavity dosure rates of 58.8% in the treatment gnup and 47.1% in the control group.The drug adverse reaction rates were 12.7% in the treatment group and 7.5% in the control group.Conclusion Lensloxacin is a new effective and safe antituberculosis drug in the treatment of pulmonary tuberculosis.