Effects of dl-para-chlorophenylalanine on sucrose preference and intake: reversal by 5-hydroxytryptophan and 6-methoxy 1,2,3,4,-tetrahydro-beta-carboline |
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| Authors: | D M Nance M M Kilbey |
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| Affiliation: | Department of Anatomy, School of Medicine, University of California, Los Angeles, California 90024, USA;Department of Biophysics, University of Houston, Houston, Texas, 77004, USA |
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| Abstract: | In two experiments involving 12- or 4-hr two-bottle preference tests, rats depleted of brain serotonin by dl-para-chlorophenylalanine (pCPA) injections consumed larger amounts of sucrose and had a higher preference for sucrose solutions over distilled water than vehicle-injected control animals. Injection of 5-hydroxytryptophan (5-HTP) or 6-methoxy-1,2,3,4-tetrahydro-β-carboline (6-MeO-THBC) was found to reverse the effects of pCPA on brain serotonin as well as reverse the increased sucrose preference produced by pCPA. |
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| Keywords: | Taste preference 5-Hydroxytryptophan Serotonin 6-Methoxy-1,2,3,4-tetrahydro-β-carboline Carbohydrate regulation |
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