The dexamethasone suppression test and CSF-5-HIAA in relation to suicidality and depression in suicide attempters. |
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Authors: | Asa Westrin Anders Niméus |
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Institution: | Department of Clinical Neuroscience, Division of Psychiatry, Lund University, 221 85 Lund, Sweden. asa.westrin@psykiatr.lu.se |
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Abstract: | This study tested suicidality in relation to cerebrospinal fluid (CSF) 5-hydroxyindoleacetic acid (5-HIAA) and the dexamethasone suppression test. Patients with nonsuppression of cortisol had the highest scores of the Suicide Assessment Scale (SUAS) and the Montgomery Asberg Depression Rating Scale (MADRS), respectively (P < 0.05; P < 0.01). The results persisted when analysed for covariance with CSF-5-HIAA. We have previously noted an elevated suicide risk in suicide attempters with high SUAS-scores, why a large part of nonsuppressors may be at high risk for future suicide. |
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