阵发性睡眠性血红蛋白尿患者血细胞的特点及临床意义

目的 探讨阵发性睡眠性血红蛋白尿(PNH)患者血细胞的特点及临床意义。方法 对刚入院的33例PNH患者通过骨髓涂片或/和活检分成2组:骨髓增生活跃组21例,占64％;骨髓增生减低组12例,占36％。将2组患者的红细胞、血红蛋白、白细胞、血小板进行比较分析。结果 2组PNH患者的血红蛋白分别为(57.47±17.87)g/L和(71.30±19.52)g/L,红细胞分别为(1.58±0.49)×10~(12)/L和(2.15±0.59)×10~(12)/L,无明显差异(P>0.05);而白细胞分别为(6.14±4.21)×10~9/L和(2.34±0.90)×10~9/L,血小板分别为(110.29±89.06)×10~9/L和(23.42±12.06)×10~9/L,有明显差异(P<0.05)。结论 结果提示,PNH患者的血红蛋白和红细胞与骨髓增生情况似无明显相关的关系;白细胞、血小板与骨髓增生可能有关。

The characteristics and clinical significance of hemocyte in patients with paroxysmal nocturnal hemoglobinura

Objective To investigate the characteristics and clinical significance of hemocyte in patients with paroxysmal nocturnal hemoglobinura (PNH) .Methods 33 cases of PNH were divided into bone marrow hyper-plasia group (21 cases,64%) and hypoplasia group (12 cases,36%) according to bone marrow smear or/and bone marrow biopsy hemoglobin,RBC,WBC and platelets were analysed in two groups.Results No significant differences were found between hyperplasia group and hypoplasia group in hemoglobin (57.47 g/L±17.87 g/L vs 71.30 g/L±19.52g/L, P >0.05),RBC(1.58×1012/L±0.49×1012/L vs 2.15×1012/L±0.59×1012/L, P >0.05).There were significant differences between hyperplasia group and hypoplasiagroup in WBC (6.14× 109/L±4.21 × 10/L vs 2.34×109/L±0.09×109/L, P <0.05)and platelets (110.29×109/L±89.06×109/L vs 23.42×109/L±12.06×109/L, P < 0.01).Conclusion The results suggest that hemoglobin and RBC have no statistic significant difference as variable cell denisity of bone marrow,but WBC and platelets have statistic significant difference.