Suppression by Candida albicans beta-glucan of cytokine release from activated human monocytes and from T cells in the presence of monocytes |
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Authors: | Nakagawa Yukari Ohno Naohito Murai Toshimi |
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Affiliation: | Division of Biological Evaluation, Osaka Branch, National Institute of Health Sciences, Osaka, Japan. yukari@nihs.go.jp |
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Abstract: | The effect of a soluble beta-glucan from Candida albicans (CSBG) on cytokine production by cultured human peripheral blood mononuclear cells (PBMC) was assessed. CSBG induced a slight increase in the spontaneous release of proinflammatory cytokines, such as interleukin (IL)-6, but significantly suppressed endotoxin-induced IL-6 production in cultures of PBMC and monocytes isolated from PBMC. CSBG also suppressed the release of type 1 cytokines, IL-2, and interferon-gamma. These findings suggest that CSBG suppresses monocyte functions directly and thus suppresses T cell function indirectly. CSBG may play a role in the development of candidiasis. |
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