Fever of Unknown Origin in
Turkey |
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Authors: | Email author" target="_blank">F?TabakEmail author A?Mert A?D?Celik R?Ozaras M?R?Altiparmak R?Ozturk Y?Aktuglu |
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Institution: | (1) Yaliboyu cad. Koruluk. Mehpare Basaran sok. No: 15/1, Beylerbeyi, 81210 Istanbul, Turkey;(2) Dept. of Clinical Bacteriology and Infectious Diseases, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey;(3) Dept. of Internal Medicine, Cerrahpasa Medical Faculty, University of Istanbul, Istanbul, Turkey |
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Abstract: | Abstract.
Background:
The etiology of fever of unknown origin (FUO) includes
primarily infectious, collagen-vascular and neoplastic diseases.
The distribution of the disorders causing FUO may differ
according to the geographic area and the socioeconomical status
of the country. Moreover, the developments in radiographic and
microbiologic methods have changed the spectrum of diseases
causing FUO.
Materials and
Methods:
We reviewed 117 cases that fulfilled the criteria of FUO
followed in our department during the period 1984 to
2001.
Results:
The etiology of FUO was infectious diseases in 34% of the
patients, collagen-vascular diseases in 23%, neoplasms in 19%
and miscellaneous diseases in 10%. In 14% of the cases the
etiology could not be found. The three leading diseases were
tuberculosis (24%), lymphomas (19%) and adult-onset Still s
disease (11%). Tuberculosis was found to be a more common cause
of FUO than reported in studies in developed countries. Invasive
procedures helped to establish the diagnosis in 50 out of 92
patients (43%). As a final diagnostic procedure, laparotomy
aided the establishment of a diagnosis in 15 out of 20 patients
(75%).
Conclusion:
Although the relative rate of infectious disease as
etiologic category is less commonly encountered, infectious
disease, especially tuberculosis, remains a common cause of FUO.
Although several diseases may lead to FUO, lymphomas,
adult-onset Still s disease and particularly tuberculosis should
be considered in the differential diagnosis of a patient
admitted with FUO. |
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Keywords: | |
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